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Slc4a3 Gene Detail
Summary
  • Symbol
    Slc4a3
  • Name
    solute carrier family 4 (anion exchanger), member 3
  • Synonyms
    A930038D23Rik, Ae3
  • Feature Type
    protein coding gene
  • IDs
    MGI:109350
    NCBI Gene: 20536
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:75522688-75536075 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 39.16 cM, cytoband C3
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    115 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109350
 protein coding gene Chr1:75522688-75538816 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016194
 protein coding gene Chr1:76133913-76149768 (+)
A/J MGP_AJ_G0016177
 protein coding gene Chr1:73476366-73492244 (+)
AKR/J MGP_AKRJ_G0016134
 protein coding gene Chr1:75517676-75533562 (+)
BALB/cJ MGP_BALBcJ_G0016132
 protein coding gene Chr1:73539255-73555158 (+)
C3H/HeJ MGP_C3HHeJ_G0015963
 protein coding gene Chr1:75842108-75857953 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016585
 protein coding gene Chr1:79087805-79103696 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014306
 protein coding gene Chr1:69032067-69049602 (+)
CAST/EiJ MGP_CASTEiJ_G0015547
 protein coding gene Chr1:75187523-75203410 (+)
CBA/J MGP_CBAJ_G0015936
 protein coding gene Chr1:81664136-81682552 (+)
DBA/2J MGP_DBA2J_G0016037
 protein coding gene Chr1:72792253-72808104 (+)
FVB/NJ MGP_FVBNJ_G0016040
 protein coding gene Chr1:72008769-72025066 (+)
LP/J MGP_LPJ_G0016109
 protein coding gene Chr1:77257807-77273659 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016060
 protein coding gene Chr1:85000220-85016133 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016632
 protein coding gene Chr1:75580153-75596005 (+)
PWK/PhJ MGP_PWKPhJ_G0015334
 protein coding gene Chr1:72270747-72286790 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015112
 protein coding gene Chr1:74935596-74951541 (+)
WSB/EiJ MGP_WSBEiJ_G0015609
 protein coding gene Chr1:75388758-75404686 (+)



Homology
more
  • Human Ortholog
    SLC4A3, solute carrier family 4 member 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC4A3, solute carrier family 4 member 3
  • Synonyms
    AE3, CAE3/BAE3, SLC2C, SQT7
  • Links
    NCBI Gene ID: 6508
    neXtProt AC: NX_P48751
    UniProt: P48751

  • Chr Location
    2q35; chr2:219627394-219641980 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotypes from multigenic genotypes
    1 images
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for one knock-out allele show inner retina defects including selective ERG b-wave depression, optic nerve and retinal vessel anomalies, sheathing of retinal vessels and late onset photoreceptor death. Homozygotes for another knock-out allele are more sensitive to seizure-inducing agents.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    977
  • Tissues
    122
  • cDNA Data
    66
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20536 NCBI Gene Model | MGI Sequence Detail 13388 C57BL/6J ±  kb
    transcript NM_009208 RefSeq | MGI Sequence Detail 4441 ZRU/MplStud  
    polypeptide P16283 UniProt | EBI | MGI Sequence Detail 1227 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 71
      Genomic 3
      cDNA 67
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1169, MGD-MRK-38395, MGI:1925074
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 7
      Phenotypes 31
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:233793 Taylor-Burds C, et al., Chloride Accumulators NKCC1 and AE2 in Mouse GnRH Neurons: Implications for GABAA Mediated Excitation. PLoS One. 2015;10(6):e0131076
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory