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Fgf12 Gene Detail
Summary
  • Symbol
    Fgf12
  • Name
    fibroblast growth factor 12
  • Synonyms
    Fhf1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109183
    NCBI Gene: 14167
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:27978850-28571820 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 19.38 cM, cytoband B1-B3
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4632 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109183
 protein coding gene Chr16:27976535-28571995 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022701
 protein coding gene Chr16:25962268-26250213 (-)
A/J MGP_AJ_G0022664
 protein coding gene Chr16:24760805-25044910 (-)
AKR/J MGP_AKRJ_G0022638
 protein coding gene Chr16:25728364-26000495 (-)
BALB/cJ MGP_BALBcJ_G0022668
 protein coding gene Chr16:24940437-25224272 (-)
C3H/HeJ MGP_C3HHeJ_G0022433
 protein coding gene Chr16:25821645-26096121 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023117
 protein coding gene Chr16:26516727-26822337 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020635
 protein coding gene Chr16:25263091-25528275 (-)
CAST/EiJ MGP_CASTEiJ_G0021961
 protein coding gene Chr16:25886124-26173429 (-)
CBA/J MGP_CBAJ_G0022403
 protein coding gene Chr16:27637124-27943561 (-)
DBA/2J MGP_DBA2J_G0022536
 protein coding gene Chr16:24658545-24938744 (-)
FVB/NJ MGP_FVBNJ_G0022511
 protein coding gene Chr16:24640869-24922010 (-)
LP/J MGP_LPJ_G0022603
 protein coding gene Chr16:25753542-26040657 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022530
 protein coding gene Chr16:27265123-27566065 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023129
 protein coding gene Chr16:25670693-25956274 (-)
PWK/PhJ MGP_PWKPhJ_G0021700
 protein coding gene Chr16:24945577-25218978 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021531
 protein coding gene Chr16:25405252-25691107 (-)
WSB/EiJ MGP_WSBEiJ_G0022005
 protein coding gene Chr16:25625021-25896573 (-)



Homology
more
  • Human Ortholog
    FGF12, fibroblast growth factor 12
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FGF12, fibroblast growth factor 12
  • Synonyms
    DEE47, EIEE47, FGF12B, FHF1
  • Links
    NCBI Gene ID: 2257
    neXtProt AC: NX_P61328
    UniProt: P61328

  • Chr Location
    3q28-q29; chr3:192139390-192767764 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human FGF12 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable, fertile, and do not exhibit any significant behavioral or neurological phenotypes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    988
  • Tissues
    230
  • cDNA Data
    32
  • Literature Summary
    27
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022523 Ensembl Gene Model | MGI Sequence Detail 592971 C57BL/6J ±  kb
transcript ENSMUST00000100024 Ensembl | MGI Sequence Detail 4137 Not Applicable  
polypeptide ENSMUSP00000097601 Ensembl | MGI Sequence Detail 243 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 46
    Genomic 1
    cDNA 35
    Primer pair 8
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-38227, MGI:2146595
References
more
  • Summaries
    All 69
    Developmental Gene Expression 27
    Gene Ontology 9
    Phenotypes 10
  • Earliest
    J:41070 Smallwood PM, et al., Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9850-7
  • Latest
    J:321503 Meuser M, et al., FGFR2 signaling enhances the SHH-BMP4 signaling axis in early ureter development. Development. 2022 Jan 1;149(1):dev200021
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory