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Ltbp1 Gene Detail
Summary
  • Symbol
    Ltbp1
  • Name
    latent transforming growth factor beta binding protein 1
  • Synonyms
    9430031G15Rik, b2b1000Clo, LTBP-1, Ltbp1L
  • Feature Type
    protein coding gene
  • IDs
    MGI:109151
    NCBI Gene: 268977
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:75312563-75699507 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 46.24 cM, cytoband E3
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2596 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109151
 protein coding gene Chr17:75312475-75699507 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024033
 protein coding gene Chr17:77690011-78111091 (+)
A/J MGP_AJ_G0023990
 protein coding gene Chr17:75276182-75668114 (+)
AKR/J MGP_AKRJ_G0023959
 protein coding gene Chr17:76394738-76788631 (+)
BALB/cJ MGP_BALBcJ_G0023992
 protein coding gene Chr17:75178078-75577069 (+)
C3H/HeJ MGP_C3HHeJ_G0023756
 protein coding gene Chr17:77293875-77695447 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024437
 protein coding gene Chr17:80480081-80894001 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021881
 protein coding gene Chr17:70891616-71279850 (+)
CAST/EiJ MGP_CASTEiJ_G0023236
 protein coding gene Chr17:77835064-78241229 (+)
CBA/J MGP_CBAJ_G0023730
 protein coding gene Chr17:83828834-84282519 (+)
DBA/2J MGP_DBA2J_G0023859
 protein coding gene Chr17:73853957-74244544 (+)
FVB/NJ MGP_FVBNJ_G0023825
 protein coding gene Chr17:73379563-73775568 (+)
LP/J MGP_LPJ_G0023942
 protein coding gene Chr17:78454437-78870953 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023853
 protein coding gene Chr17:83636401-84057101 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024481
 protein coding gene Chr17:76841695-77259373 (+)
PWK/PhJ MGP_PWKPhJ_G0022982
 protein coding gene Chr17:73257201-73666766 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022793
 protein coding gene Chr17:73580156-74007545 (+)
WSB/EiJ MGP_WSBEiJ_G0023303
 protein coding gene Chr17:77716306-78132787 (+)



Homology
more
  • Human Ortholog
    LTBP1, latent transforming growth factor beta binding protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LTBP1, latent transforming growth factor beta binding protein 1
  • Synonyms
    ARCL2E
  • Links
    NCBI Gene ID: 4052
    neXtProt AC: NX_Q14766
    UniProt: Q14766

  • Chr Location
    2p22.3; chr2:32946953-33399509 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human LTBP1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    50 phenotypes from 6 alleles in 5 genetic backgrounds
    15 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic and neonatal lethality associated with defects in the aortic arch and outflow tract.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1203
  • Tissues
    303
  • cDNA Data
    67
  • Literature Summary
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001870 Ensembl Gene Model | MGI Sequence Detail 386945 C57BL/6J ±  kb
    transcript ENSMUST00000234490 Ensembl | MGI Sequence Detail 6235 Not Applicable  
    polypeptide ENSMUSP00000157016 Ensembl | MGI Sequence Detail 1713 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 74
      cDNA 69
      Primer pair 5

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-38195, MGI:1924572, MGI:5316769
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 22
      Gene Ontology 14
      Phenotypes 19
    • Earliest
      J:24946 Yin W, et al., Isolation of a novel latent transforming growth factor-beta binding protein gene (LTBP-3). J Biol Chem. 1995 Apr 28;270(17):10147-60
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory