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Taf6 Gene Detail
Summary
  • Symbol
    Taf6
  • Name
    TATA-box binding protein associated factor 6
  • Synonyms
    80kDa, p80, Taf2e
  • Feature Type
    protein coding gene
  • IDs
    MGI:109129
    NCBI Gene: 21343
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:138176879-138185713 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 76.98 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    67 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109129
 protein coding gene Chr5:138176879-138185713 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030259
 protein coding gene Chr5:142974579-142983387 (-)
A/J MGP_AJ_G0030227
 protein coding gene Chr5:136792995-136801814 (-)
AKR/J MGP_AKRJ_G0030159
 protein coding gene Chr5:141245644-141254465 (-)
BALB/cJ MGP_BALBcJ_G0030241
 protein coding gene Chr5:138152607-138161421 (-)
C3H/HeJ MGP_C3HHeJ_G0029954
 protein coding gene Chr5:141873086-141881899 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030688
 protein coding gene Chr5:148327975-148336808 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027906
 protein coding gene Chr5:130927097-130936026 (-)
CAST/EiJ MGP_CASTEiJ_G0029360
 protein coding gene Chr5:141254698-141263519 (-)
CBA/J MGP_CBAJ_G0029925
 protein coding gene Chr5:154204891-154213712 (-)
DBA/2J MGP_DBA2J_G0030073
 protein coding gene Chr5:136692453-136701271 (-)
FVB/NJ MGP_FVBNJ_G0030031
 protein coding gene Chr5:135856864-135865687 (-)
LP/J MGP_LPJ_G0030162
 protein coding gene Chr5:143514560-143523384 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030062
 protein coding gene Chr5:157030297-157039116 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030729
 protein coding gene Chr5:141081192-141090011 (-)
PWK/PhJ MGP_PWKPhJ_G0029074
 protein coding gene Chr5:135751227-135759819 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028910
 protein coding gene Chr5:138641925-138650626 (-)
WSB/EiJ MGP_WSBEiJ_G0029435
 protein coding gene Chr5:141770618-141779464 (-)



Homology
more
  • Human Ortholog
    TAF6, TATA-box binding protein associated factor 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TAF6, TATA-box binding protein associated factor 6
  • Synonyms
    ALYUS, MGC:8964, TAF2E, TAFII70, TAF(II)70, TAFII-70, TAFII80, TAF(II)80, TAFII-80, TAFII85
  • Links
    NCBI Gene ID: 6878
    neXtProt AC: NX_P49848
    UniProt: P49848

  • Chr Location
    7q22.1; chr7:100106876-100127171 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a transgenic gene disruption may exhibit preimplantation lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    872
  • Tissues
    98
  • cDNA Data
    52
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21343 NCBI Gene Model | MGI Sequence Detail 8835 C57BL/6J ±  kb
    transcript NM_001356600 RefSeq | MGI Sequence Detail 2411 C57BL/6  
    polypeptide Q62311 UniProt | EBI | MGI Sequence Detail 678 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000016031 transcription initiation factor TFIID subunit 6
      (term hierarchy)
    • InterPro Domains
      IPR016024 Armadillo-type fold
      IPR009072 Histone-fold
      IPR011442 TAF6, C-terminal HEAT repeat domain
      IPR046344 TAF6, C-terminal HEAT repeat domain superfamily
      IPR004823 TATA box binding protein associated factor (TAF), histone-like fold domain
      IPR037796 Transcription initiation factor TFIID subunit 6
    Molecular
    Reagents
    less
    • All nucleic 57
      cDNA 53
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-38173, MGI:2141226
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 14
      Gene Ontology 14
      Phenotypes 13
    • Earliest
      J:28371 Umehara T, et al., Isolation of a cDNA encoding a mouse TFIID subunit containing histone H4 homology. Gene. 1995 Aug 19;161(2):301-2
    • Latest
      J:337771 El-Saafin F, et al., Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death. Cell Death Differ. 2022 May;29(5):1013-1027
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory