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Prkg2 Gene Detail
Summary
  • Symbol
    Prkg2
  • Name
    protein kinase, cGMP-dependent, type II
  • Synonyms
    cGK-II, Prkgr2
  • Feature Type
    protein coding gene
  • IDs
    MGI:108173
    NCBI Gene: 19092
  • Alliance
    genome feature page
  • Transcription Start Sites
    12 TSS
  • Regulated by
    Rr1399 (1 regulatory region)
Location &
Maps
more
  • Sequence Map
    Chr5:99077632-99185042 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 48.35 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3216 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108173
 protein coding gene Chr5:99077632-99185210 (-)
129S1/SvImJ ENSMUSG00200005105
 protein coding gene Chr5:92812479-92920307 (-)
A/J ENSMUSG00195032488
 protein coding gene Chr5:92360913-92468746 (-)
AKR/J ENSMUSG00220032293
 protein coding gene Chr5:91830448-91938269 (-)
BALB/cJ ENSMUSG00180029570
 protein coding gene Chr5:92517133-92624958 (-)
C3H/HeJ ENSMUSG00175029012
 protein coding gene Chr5:94615427-94723241 (-)
C57BL/6NJ ENSMUSG00215011364
 protein coding gene Chr5:92460969-92568827 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027443
 protein coding gene Chr5:91884344-91993650 (-)
CAST/EiJ ENSTCUG00005023595
 protein coding gene Chr5:91861213-91968771 (-)
CBA/J ENSMUSG00210033111
 protein coding gene Chr5:93374487-93482298 (-)
DBA/2J ENSMUSG00185034841
 protein coding gene Chr5:96290514-96398335 (-)
FVB/NJ ENSMUSG00205038836
 protein coding gene Chr5:92274959-92382781 (-)
JF1/MsJ ENSUMUG00000035312
 protein coding gene Chr5:99290939-99398979 (-)
LP/J ENSMUSG00230025698
 protein coding gene Chr5:100354281-100462108 (-)
NOD/ShiLtJ ENSMUSG00190021241
 protein coding gene Chr5:92286477-92394308 (-)
NZO/HlLtJ ENSMUSG00225012279
 protein coding gene Chr5:108106382-108214198 (-)
PWK/PhJ ENSLUMG00010013124
 protein coding gene Chr5:91407935-91516045 (-)
SPRET/EiJ ENSMSPG00010022334
 protein coding gene Chr5:94309096-94416530 (-)
WSB/EiJ ENSIUOG00005030114
 protein coding gene Chr5:95023504-95131406 (-)



Homology
more
  • Human Ortholog
    PRKG2, protein kinase cGMP-dependent 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRKG2, protein kinase cGMP-dependent 2
  • Synonyms
    AMD4, cGK2, cGKII, PKG2, PRKGR2, SMDP
  • Links
    NCBI Gene ID: 5593
    UniProt: Q13237

  • Chr Location
    4q21.21; chr4:81086874-81217970 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PRKG2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 1 allele in 1 genetic background
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit dwarfism, with abnormal skull morphology and short limbs and vertebrae. Defects in axial organization of the growth plates was evident as mice aged. Digestive secretion in response to enterotoxin was reduced.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    616
  • Tissues
    10
  • cDNA Data
    18
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19092 NCBI Gene Model | MGI Sequence Detail 107411 C57BL/6J ±  kb
    transcript NM_008926 RefSeq | MGI Sequence Detail 4696 ZRU/MplStud  
    polypeptide Q61410 UniProt | EBI | MGI Sequence Detail 762 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 1
      cDNA 18
      Primer pair 3
      Antibodies 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-19671, MGD-MRK-37212, MGI:2141175
    References
    more
    • Summaries
      All 79
      Developmental Gene Expression 5
      Gene Ontology 14
      Phenotypes 29
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:347239 Kalyanaraman H, et al., Protein Kinase G2 Is Essential for Skeletal Homeostasis and Adaptation to Mechanical Loading in Male but Not Female Mice. J Bone Miner Res. 2023 Jan;38(1):171-185
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    09/08/2026
    MGI 6.24     		The Jackson Laboratory