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Prkg2 Gene Detail
Summary
  • Symbol
    Prkg2
  • Name
    protein kinase, cGMP-dependent, type II
  • Synonyms
    cGK-II, Prkgr2
  • Feature Type
    protein coding gene
  • IDs
    MGI:108173
    NCBI Gene: 19092
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:99077632-99185042 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 48.35 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    864 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108173
 protein coding gene Chr5:99077632-99185210 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029777
 protein coding gene Chr5:100306931-100416820 (-)
A/J MGP_AJ_G0029743
 protein coding gene Chr5:96599524-96707231 (-)
AKR/J MGP_AKRJ_G0029689
 protein coding gene Chr5:99796859-99906247 (-)
BALB/cJ MGP_BALBcJ_G0029753
 protein coding gene Chr5:97613849-97722583 (-)
C3H/HeJ MGP_C3HHeJ_G0029476
 protein coding gene Chr5:100126508-100235258 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030208
 protein coding gene Chr5:104526568-104641897 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027443
 protein coding gene Chr5:91884344-91993650 (-)
CAST/EiJ MGP_CASTEiJ_G0028887
 protein coding gene Chr5:98756455-98871142 (-)
CBA/J MGP_CBAJ_G0029446
 protein coding gene Chr5:108118427-108229773 (-)
DBA/2J MGP_DBA2J_G0029590
 protein coding gene Chr5:96786713-96899225 (-)
FVB/NJ MGP_FVBNJ_G0029549
 protein coding gene Chr5:95604335-95712501 (-)
LP/J MGP_LPJ_G0029678
 protein coding gene Chr5:100917170-101029253 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029578
 protein coding gene Chr5:113241090-113360260 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030241
 protein coding gene Chr5:99237312-99357531 (-)
PWK/PhJ MGP_PWKPhJ_G0028605
 protein coding gene Chr5:95220440-95329848 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028440
 protein coding gene Chr5:96935471-97057795 (-)
WSB/EiJ MGP_WSBEiJ_G0028965
 protein coding gene Chr5:99576430-99688598 (-)



Homology
more
  • Human Ortholog
    PRKG2, protein kinase cGMP-dependent 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRKG2, protein kinase cGMP-dependent 2
  • Synonyms
    AMD4, cGK2, cGKII, PKG2, PRKGR2, SMDP
  • Links
    NCBI Gene ID: 5593
    neXtProt AC: NX_Q13237
    UniProt: Q13237

  • Chr Location
    4q21.21; chr4:81087370-81217836 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PRKG2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 1 allele in 1 genetic background
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit dwarfism, with abnormal skull morphology and short limbs and vertebrae. Defects in axial organization of the growth plates was evident as mice aged. Digestive secretion in response to enterotoxin was reduced.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    725
  • Tissues
    10
  • cDNA Data
    18
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19092 NCBI Gene Model | MGI Sequence Detail 107411 C57BL/6J ±  kb
    transcript NM_008926 RefSeq | MGI Sequence Detail 4696 ZRU/MplStud  
    polypeptide Q61410 UniProt | EBI | MGI Sequence Detail 762 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 1
      cDNA 18
      Primer pair 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-19671, MGD-MRK-37212, MGI:2141175
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 5
      Gene Ontology 9
      Phenotypes 27
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:326293 Islam BN, et al., Type-2 cGMP-dependent protein kinase suppresses proliferation and carcinogenesis in the colon epithelium. Carcinogenesis. 2022 Jun 27;43(6):584-593
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    04/16/2024
    MGI 6.23     		The Jackson Laboratory