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Uqcrc1 Gene Detail
Summary
  • Symbol
    Uqcrc1
  • Name
    ubiquinol-cytochrome c reductase core protein 1
  • Synonyms
    1110032G10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:107876
    NCBI Gene: 22273
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:108765701-108778691 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 59.63 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    42 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107876
 protein coding gene Chr9:108765701-108778709 (+)
129S1/SvImJ ENSMUSG00200039190
 protein coding gene Chr9:105961930-105974948 (+)
A/J ENSMUSG00195038025
 protein coding gene Chr9:105181164-105194167 (+)
AKR/J ENSMUSG00220026927
 protein coding gene Chr9:105568481-105581486 (+)
BALB/cJ ENSMUSG00180022527
 protein coding gene Chr9:105497639-105510646 (+)
C3H/HeJ ENSMUSG00175044771
 protein coding gene Chr9:105839890-105852893 (+)
C57BL/6NJ ENSMUSG00215040842
 protein coding gene Chr9:105818491-105831512 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032708
 protein coding gene Chr9:104222155-104234228 (+)
CAST/EiJ ENSTCUG00005034190
 protein coding gene Chr9:105594099-105606986 (+)
CBA/J ENSMUSG00210040236
 protein coding gene Chr9:105692572-105704715 (+)
DBA/2J ENSMUSG00185033186
 protein coding gene Chr9:105849318-105862323 (+)
FVB/NJ ENSMUSG00205032637
 protein coding gene Chr9:105850696-105863702 (+)
JF1/MsJ ENSUMUG00000054099
 protein coding gene Chr9:105681898-105694037 (+)
LP/J ENSMUSG00230049964
 protein coding gene Chr9:105990744-106003761 (+)
NOD/ShiLtJ ENSMUSG00190034905
 protein coding gene Chr9:105487724-105500725 (+)
NZO/HlLtJ ENSMUSG00225024311
 protein coding gene Chr9:106222505-106235508 (+)
PWK/PhJ ENSLUMG00010041881
 protein coding gene Chr9:105646405-105658564 (+)
SPRET/EiJ ENSMSPG00010045564
 protein coding gene Chr9:107471846-107484120 (+)
WSB/EiJ ENSIUOG00005042902
 protein coding gene Chr9:104938798-104951813 (+)



Homology
more
  • Human Ortholog
    UQCRC1, ubiquinol-cytochrome c reductase core protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UQCRC1, ubiquinol-cytochrome c reductase core protein 1
  • Synonyms
    D3S3191, PKNPY, QCR1, UQCR1
  • Links
    NCBI Gene ID: 7384
    UniProt: P31930

  • Chr Location
    3p21.31; chr3:48599002-48610976 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human UQCRC1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout is early embryonic lethal. Heterozygous KO impairs memory and spatial learning and increases susceptibility to brain ischemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    871
  • Tissues
    154
  • cDNA Data
    396
  • Literature Summary
    10
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025651 Ensembl Gene Model | MGI Sequence Detail 12991 C57BL/6J ±  kb
transcript ENSMUST00000026743 Ensembl | MGI Sequence Detail 1653 Not Applicable  
polypeptide ENSMUSP00000026743 Ensembl | MGI Sequence Detail 480 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 398
    cDNA 396
    Primer pair 2
    Antibodies 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-36453, MGI:1913436
References
more
  • Summaries
    All 71
    Developmental Gene Expression 10
    Gene Ontology 20
    Phenotypes 15
  • Earliest
    J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
  • Latest
    J:376044 Hao Z, et al., Microprotein PLUM encoded by Lin28b uORF is a cytoplasmic determinant of pluripotency and embryonic development. Nat Commun. 2025 Nov 26;16(1):10324
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory