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Pum3 Gene Detail
Summary
  • Symbol
    Pum3
  • Name
    pumilio RNA-binding family member 3
  • Synonyms
    1110069H02Rik, D19Bwg1357e
  • Feature Type
    protein coding gene
  • IDs
    MGI:106253
    NCBI Gene: 52874
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:27366098-27407225 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 19, 21.96 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    243 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106253
protein coding gene Chr19:27366098-27407264 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025009
protein coding gene Chr19:25755863-25792464 (-)
A/J MGP_AJ_G0024986
protein coding gene Chr19:24428334-24463632 (-)
AKR/J MGP_AKRJ_G0024954
protein coding gene Chr19:25349276-25384511 (-)
BALB/cJ MGP_BALBcJ_G0024985
protein coding gene Chr19:24467211-24503174 (-)
C3H/HeJ MGP_C3HHeJ_G0024741
protein coding gene Chr19:25308944-25347833 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025426
protein coding gene Chr19:26497490-26533788 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022845
protein coding gene Chr19:24444360-24479348 (-)
CAST/EiJ MGP_CASTEiJ_G0024211
protein coding gene Chr19:25086019-25121770 (-)
CBA/J MGP_CBAJ_G0024719
protein coding gene Chr19:27746831-27784643 (-)
DBA/2J MGP_DBA2J_G0024851
protein coding gene Chr19:24398801-24433923 (-)
FVB/NJ MGP_FVBNJ_G0024813
protein coding gene Chr19:24249220-24284388 (-)
LP/J MGP_LPJ_G0024936
protein coding gene Chr19:25737573-25778335 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024840
protein coding gene Chr19:27667256-27702581 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025481
protein coding gene Chr19:25345386-25387372 (-)
PWK/PhJ MGP_PWKPhJ_G0023959
protein coding gene Chr19:24039300-24074217 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023763
protein coding gene Chr19:24567417-24604075 (-)
WSB/EiJ MGP_WSBEiJ_G0024278
protein coding gene Chr19:25363592-25400771 (-)



Homology
more
  • Human Ortholog
    PUM3, pumilio RNA binding family member 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PUM3, pumilio RNA binding family member 3
  • Synonyms
    HA-8, HLA-HA8, KIAA0020, PEN, PUF6, PUF-A, XTP5
  • Links
    NCBI Gene ID: 9933
    neXtProt AC: NX_Q15397
    UniProt: Q15397

  • Chr Location
    9p24.2; chr9:2720469-2844095 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice hemizygous for an inducible knockdown transgenic allele display loss of primordial germ cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041360 Ensembl Gene Model | MGI Sequence Detail 41128 C57BL/6J ±  kb
transcript ENSMUST00000076219 Ensembl | MGI Sequence Detail 3471 Not Applicable  
polypeptide ENSMUSP00000075573 Ensembl | MGI Sequence Detail 648 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 196
    cDNA 194
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-33945, MGI:1916135, MGI:2147458
References
more
  • Summaries
    All 40
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
  • Latest
    J:338852 Ko CF, et al., The Puf-A Protein Is Required for Primordial Germ Cell Development. Cells. 2022 Apr 27;11(9)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory