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Pum3 Gene Detail
Summary
  • Symbol
    Pum3
  • Name
    pumilio RNA-binding family member 3
  • Synonyms
    1110069H02Rik, D19Bwg1357e
  • Feature Type
    protein coding gene
  • IDs
    MGI:106253
    NCBI Gene: 52874
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:27366098-27407225 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 21.96 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1095 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106253
 protein coding gene Chr19:27366098-27407264 (-)
129S1/SvImJ ENSMUSG00200020337
 protein coding gene Chr19:24082615-24123957 (-)
A/J ENSMUSG00195035110
 protein coding gene Chr19:24258038-24299178 (-)
AKR/J ENSMUSG00220018722
 protein coding gene Chr19:24303422-24344570 (-)
BALB/cJ ENSMUSG00180013259
 protein coding gene Chr19:24579452-24620575 (-)
C3H/HeJ ENSMUSG00175024140
 protein coding gene Chr19:23955829-23996957 (-)
C57BL/6NJ ENSMUSG00215025289
 protein coding gene Chr19:23996156-24037284 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022845
 protein coding gene Chr19:24444360-24479348 (-)
CAST/EiJ ENSTCUG00005018036
 protein coding gene Chr19:23834236-23869132 (-)
CBA/J ENSMUSG00210014285
 protein coding gene Chr19:24186803-24227927 (-)
DBA/2J ENSMUSG00185025799
 protein coding gene Chr19:24573533-24614663 (-)
FVB/NJ ENSMUSG00205011992
 protein coding gene Chr19:23966326-24007466 (-)
JF1/MsJ ENSUMUG00000033031
 protein coding gene Chr19:24790025-24824809 (-)
LP/J ENSMUSG00230027324
 protein coding gene Chr19:25392027-25433367 (-)
NOD/ShiLtJ ENSMUSG00190021246
 protein coding gene Chr19:23950290-23991418 (-)
NZO/HlLtJ ENSMUSG00225033385
 protein coding gene Chr19:29142887-29184223 (-)
PWK/PhJ ENSLUMG00010031446
 protein coding gene Chr19:24163981-24198760 (-)
SPRET/EiJ ENSMSPG00010034202
 protein coding gene Chr19:24122579-24157854 (-)
WSB/EiJ ENSIUOG00005026262
 protein coding gene Chr19:23683113-23724250 (-)



Homology
more
  • Human Ortholog
    PUM3, pumilio RNA binding family member 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PUM3, pumilio RNA binding family member 3
  • Synonyms
    HA-8, HLA-HA8, KIAA0020, PEN, PUF6, PUF-A, XTP5
  • Links
    NCBI Gene ID: 9933
    UniProt: Q15397

  • Chr Location
    9p24.2; chr9:2720469-2844130 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice hemizygous for an inducible knockdown transgenic allele display loss of primordial germ cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    600
  • Tissues
    3
  • cDNA Data
    191
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041360 Ensembl Gene Model | MGI Sequence Detail 41128 C57BL/6J ±  kb
    transcript ENSMUST00000076219 Ensembl | MGI Sequence Detail 3471 Not Applicable  
    polypeptide ENSMUSP00000075573 Ensembl | MGI Sequence Detail 647 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 196
      cDNA 194
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-33945, MGI:1916135, MGI:2147458
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 14
    • Earliest
      J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
    • Latest
      J:380616 Lv X, et al., TRIB3 promotes pulmonary fibrosis through inhibiting SLUG degradation by physically interacting with MDM2. Acta Pharm Sin B. 2023 Apr;13(4):1631-1647
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory