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Cox8a Gene Detail
Summary
  • Symbol
    Cox8a
  • Name
    cytochrome c oxidase subunit 8A
  • Synonyms
    COX8L, COX VIII-L
  • Feature Type
    protein coding gene
  • IDs
    MGI:105959
    NCBI Gene: 12868
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:7192523-7194981 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 5.28 cM, cytoband A
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    109 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105959
 protein coding gene Chr19:7192518-7194981 (-)
129S1/SvImJ ENSMUSG00200051606
 protein coding gene Chr19:3918056-3920519 (-)
A/J ENSMUSG00195049641
 protein coding gene Chr19:4319971-4322434 (-)
AKR/J ENSMUSG00220037759
 protein coding gene Chr19:4089360-4091823 (-)
BALB/cJ ENSMUSG00180046883
 protein coding gene Chr19:4683526-4685991 (-)
C3H/HeJ ENSMUSG00175011747
 protein coding gene Chr19:3939977-3942441 (-)
C57BL/6NJ ENSMUSG00215046517
 protein coding gene Chr19:4158490-4160953 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022633
 protein coding gene Chr19:3886273-3888907 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210049944
 protein coding gene Chr19:3943107-3945566 (-)
DBA/2J ENSMUSG00185048540
 protein coding gene Chr19:4319583-4322042 (-)
FVB/NJ ENSMUSG00205049518
 protein coding gene Chr19:4317462-4319920 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230053911
 protein coding gene Chr19:5244778-5247241 (-)
NOD/ShiLtJ ENSMUSG00190046788
 protein coding gene Chr19:3851240-3853703 (-)
NZO/HlLtJ ENSMUSG00225026771
 protein coding gene Chr19:8953597-8956060 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    COX8A, cytochrome c oxidase subunit 8A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COX8A, cytochrome c oxidase subunit 8A
  • Synonyms
    COX, COX8, COX8-2, COX8L, MC4DN15, VIII, VIII-L
  • Links
    NCBI Gene ID: 1351
    UniProt: P10176

  • Chr Location
    11q13.1; chr11:63974620-63976543 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human COX8A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    691
  • Tissues
    94
  • cDNA Data
    407
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 12868 NCBI Gene Model | MGI Sequence Detail 2459 C57BL/6J ±  kb
transcript NM_007750 RefSeq | MGI Sequence Detail 545 C57BL/6  
polypeptide Q64445 UniProt | EBI | MGI Sequence Detail 69 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 409
    cDNA 407
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-33638
References
more
  • Summaries
    All 44
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 6
  • Earliest
    J:22802 Lomax MI, et al., Structure and chromosomal location of the bovine gene for the heart muscle isoform of cytochrome c oxidase subunit VIII. Mamm Genome. 1995 Feb;6(2):118-22
  • Latest
    J:345617 Beutner G, et al., Coordinated metabolic responses to cyclophilin D deletion in the developing heart. iScience. 2024 Mar 15;27(3):109157
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory