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Atp2b2 Gene Detail
Summary
  • Symbol
    Atp2b2
  • Name
    ATPase, Ca++ transporting, plasma membrane 2
  • Synonyms
    D6Abb2e, Gena300, jog, PMCA2, Tmy, wms
  • Feature Type
    protein coding gene
  • IDs
    MGI:105368
    NCBI Gene: 11941
  • Alliance
    genome feature page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:113720803-114019574 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 52.85 cM
  • Mapping Data
    24 experiments
Strain
Comparison
more
  • SNPs within 2kb
    8171 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105368
 protein coding gene Chr6:113720792-114019574 (-)
129S1/SvImJ ENSMUSG00200023608
 protein coding gene Chr6:110770583-111067971 (-)
A/J ENSMUSG00195015370
 protein coding gene Chr6:110443040-110741355 (-)
AKR/J ENSMUSG00220035343
 protein coding gene Chr6:109374144-109672456 (-)
BALB/cJ ENSMUSG00180002355
 protein coding gene Chr6:110807762-111106079 (-)
C3H/HeJ ENSMUSG00175030155
 protein coding gene Chr6:66294654-66592934 (+)
C57BL/6NJ ENSMUSG00215020001
 protein coding gene Chr6:110802208-111100505 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028741
 protein coding gene Chr6:108851636-109155887 (-)
CAST/EiJ ENSTCUG00005028201
 protein coding gene Chr6:110611769-110909371 (-)
CBA/J ENSMUSG00210020150
 protein coding gene Chr6:110634068-110932355 (-)
DBA/2J ENSMUSG00185018146
 protein coding gene Chr6:111005280-111303910 (-)
FVB/NJ ENSMUSG00205018373
 protein coding gene Chr6:109702983-110001196 (-)
JF1/MsJ ENSUMUG00000014441
 protein coding gene Chr6:109735473-110034443 (-)
LP/J ENSMUSG00230046987
 protein coding gene Chr6:112271942-112569256 (-)
NOD/ShiLtJ ENSMUSG00190017863
 protein coding gene Chr6:110206924-110505494 (-)
NZO/HlLtJ ENSMUSG00225047054
 protein coding gene Chr6:114219493-114518132 (-)
PWK/PhJ ENSLUMG00010027402
 protein coding gene Chr6:109230020-109528379 (-)
SPRET/EiJ ENSMSPG00010035286
 protein coding gene Chr6:111996746-112097592 (-)
WSB/EiJ ENSIUOG00005023553
 protein coding gene Chr6:110953970-111252453 (-)



Homology
more
  • Human Ortholog
    ATP2B2, ATPase plasma membrane Ca2+ transporting 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATP2B2, ATPase plasma membrane Ca2+ transporting 2
  • Synonyms
    DFNA82, PMCA2, PMCA2a, PMCA2i
  • Links
    NCBI Gene ID: 491
    UniProt: Q01814

  • Chr Location
    3p25.3; chr3:10324023-10708116 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ATP2B2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    85 phenotypes from 14 alleles in 20 genetic backgrounds
    21 phenotypes from multigenic genotypes
    4 images
    71 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit slower growth, balance problems, and deafness, associated with cerebellar abnormalities, an absence of otoconia, and abnormalities of the organ of Corti. Heterozygotes exhibit appreciable age-dependent hearing loss.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    125
  • GO References
    33
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    791
  • Tissues
    129
  • cDNA Data
    10
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11941 NCBI Gene Model | MGI Sequence Detail 298772 C57BL/6J ±  kb
    transcript NR_176856 RefSeq | MGI Sequence Detail 9219 ZRU/MplStud  
    polypeptide Q9R0K7 UniProt | EBI | MGI Sequence Detail 1198 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 9
      cDNA 13
      Primer pair 6
      Antibodies 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-15437, MGD-MRK-15460, MGD-MRK-32111, MGD-MRK-33037, MGD-MRK-8835, MGI:2158365, MGI:3664090, MGI:5490332, MGI:94888, MGI:98965
    References
    more
    • Summaries
      All 141
      Developmental Gene Expression 16
      Gene Ontology 33
      Phenotypes 71
    • Earliest
      J:19948 Matsui K, et al., [Fundamental study on ataxic mice (wriggle mouse Sagami)]. Jikken Dobutsu. 1987 Apr;36(2):185-9
    • Latest
      J:386463 Rias E, et al., Protocol for isolation of total RNA from mouse whole cochlea using organic solvents. STAR Protoc. 2026 Mar 20;7(1):104376
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory