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P2ry2 Gene Detail
Summary
  • Symbol
    P2ry2
  • Name
    purinergic receptor P2Y, G-protein coupled 2
  • Synonyms
    P2Y2
  • Feature Type
    protein coding gene
  • IDs
    MGI:105107
    NCBI Gene: 18442
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:100645775-100661260 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 54.47 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    535 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105107
 protein coding gene Chr7:100645775-100662073 (-)
129S1/SvImJ ENSMUSG00200048709
 protein coding gene Chr7:87475261-87491772 (-)
A/J ENSMUSG00195053637
 protein coding gene Chr7:91980776-91997285 (-)
AKR/J ENSMUSG00220051087
 protein coding gene Chr7:85397412-85413921 (-)
BALB/cJ ENSMUSG00180030516
 protein coding gene Chr7:88653721-88670233 (-)
C3H/HeJ ENSMUSG00175023760
 protein coding gene Chr7:89314362-89330899 (-)
C57BL/6NJ ENSMUSG00215019413
 protein coding gene Chr7:88492089-88508626 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030057
 protein coding gene Chr7:103673199-103688792 (-)
CAST/EiJ ENSTCUG00005052198
 protein coding gene Chr7:91899251-91915763 (-)
CBA/J ENSMUSG00210024986
 protein coding gene Chr7:89167909-89184446 (-)
DBA/2J ENSMUSG00185056692
 protein coding gene Chr7:93489524-93506067 (-)
FVB/NJ ENSMUSG00205030782
 protein coding gene Chr7:89151923-89168436 (-)
JF1/MsJ ENSUMUG00000029880
 protein coding gene Chr7:98391326-98407871 (-)
LP/J ENSMUSG00230041723
 protein coding gene Chr7:99617026-99633535 (-)
NOD/ShiLtJ ENSMUSG00190020751
 protein coding gene Chr7:89432314-89448823 (-)
NZO/HlLtJ ENSMUSG00225049261
 protein coding gene Chr7:97795018-97811584 (-)
PWK/PhJ ENSLUMG00010044817
 protein coding gene Chr7:87641950-87658486 (-)
SPRET/EiJ ENSMSPG00010010639
 protein coding gene Chr7:88881174-88897217 (-)
WSB/EiJ ENSIUOG00005010374
 protein coding gene Chr7:89781441-89798016 (-)



Homology
more
  • Human Ortholog
    P2RY2, purinergic receptor P2Y2
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    P2RY2, purinergic receptor P2Y2
  • Synonyms
    HP2U, P2RU1, P2U, P2U1, P2UR, P2Y2, P2Y2R
  • Links
    NCBI Gene ID: 5029
    UniProt: P41231

  • Chr Location
    11q13.4; chr11:73216664-73242427 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 3 genetic backgrounds
    93 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene display reduced nucleotide-stimulated calcium secretion from lung fibroblasts and nasal and tracheal epithelial cells and chloride secretion from trachea and gallbladder. Induction of neuronal differentiationby ATPgammaS is abolished.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    610
  • Tissues
    3
  • cDNA Data
    18
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18442 NCBI Gene Model | MGI Sequence Detail 15486 C57BL/6J ±  kb
    transcript NM_008773 RefSeq | MGI Sequence Detail 3011 C57BL/6  
    polypeptide P35383 UniProt | EBI | MGI Sequence Detail 373 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 18
      Primer pair 1
      Antibodies 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-32147
    References
    more
    • Summaries
      All 149
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 93
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:385722 Skovsted GF, et al., Role of S1P- and Rho-kinase signalling in age-related myogenic tone deficiency in murine resistance arteries. Exp Physiol. 2026 Mar;111(3):1524-1542
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory