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Rab10 Gene Detail
Summary
  • Symbol
    Rab10
  • Name
    RAB10, member RAS oncogene family
  • Feature Type
    protein coding gene
  • IDs
    MGI:105066
    NCBI Gene: 19325
  • Alliance
    gene page
  • Transcription Start Sites
    23 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:3297428-3359969 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 1.71 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    199 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105066
 protein coding gene Chr12:3297428-3359969 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019555
 protein coding gene Chr12:19782-86705 (-)
A/J MGP_AJ_G0019522
 protein coding gene Chr12:114351-178310 (-)
AKR/J MGP_AKRJ_G0019492
 protein coding gene Chr12:212832-282275 (-)
BALB/cJ MGP_BALBcJ_G0019497
 protein coding gene Chr12:106633-169049 (-)
C3H/HeJ MGP_C3HHeJ_G0019303
 protein coding gene Chr12:15774-80215 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019947
 protein coding gene Chr12:38418-110869 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017571
 protein coding gene Chr12:59622-116402 (-)
CAST/EiJ MGP_CASTEiJ_G0018858
 protein coding gene Chr12:60411-125407 (-)
CBA/J MGP_CBAJ_G0019274
 protein coding gene Chr12:239200-305341 (-)
DBA/2J MGP_DBA2J_G0019387
 protein coding gene Chr12:66262-132201 (-)
FVB/NJ MGP_FVBNJ_G0019378
 protein coding gene Chr12:83467-150799 (-)
LP/J MGP_LPJ_G0019458
 protein coding gene Chr12:59516-125670 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019411
 protein coding gene Chr12:66102-138752 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019985
 protein coding gene Chr12:14153-77513 (-)
PWK/PhJ MGP_PWKPhJ_G0018624
 protein coding gene Chr12:66333-134323 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018415
 protein coding gene Chr12:73957-148060 (-)
WSB/EiJ MGP_WSBEiJ_G0018910
 protein coding gene Chr12:43309-112955 (-)



Homology
more
  • Human Ortholog
    RAB10, RAB10, member RAS oncogene family
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAB10, RAB10, member RAS oncogene family
  • Links
    NCBI Gene ID: 10890
    neXtProt AC: NX_P61026
    UniProt: P61026

  • Chr Location
    2p23.3; chr2:26033285-26137454 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 3 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic growth and development at E7.5 with reduced cell proliferation and complete resorption by E9.5. Mice homozygous for a conditional allele activated in hepatocytes exhibit hepatic insulin resistance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    73
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    715
  • Tissues
    8
  • cDNA Data
    25
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19325 NCBI Gene Model | MGI Sequence Detail 62542 C57BL/6J ±  kb
    transcript NM_016676 RefSeq | MGI Sequence Detail 3531 ZRU/MplStud  
    polypeptide P61027 UniProt | EBI | MGI Sequence Detail 200 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 28
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-32105, MGI:2145003
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 3
      Gene Ontology 15
      Phenotypes 16
    • Earliest
      J:30578 Barbosa MD, et al., The Rab protein family: genetic mapping of six Rab genes in the mouse. Genomics. 1995 Dec 10;30(3):439-44
    • Latest
      J:340074 Wu J, et al., EHBP1L1, an apicobasal polarity regulator, is critical for nuclear polarization during enucleation of erythroblasts. Blood Adv. 2023 Jul 25;7(14):3382-3394
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory