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Adra1b Gene Detail
Summary
  • Symbol
    Adra1b
  • Name
    adrenergic receptor, alpha 1b
  • Synonyms
    alpha1B-adrenergic receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:104774
    NCBI Gene: 11548
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:43665433-43792037 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 25.81 cM
  • Mapping Data
    19 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3495 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104774
 protein coding gene Chr11:43665432-43792076 (-)
129S1/SvImJ ENSMUSG00200006812
 protein coding gene Chr11:40738978-40866180 (-)
A/J ENSMUSG00195006990
 protein coding gene Chr11:40691336-40818531 (-)
AKR/J ENSMUSG00220003258
 protein coding gene Chr11:40890221-41019766 (-)
BALB/cJ ENSMUSG00180001738
 protein coding gene Chr11:40683391-40810604 (-)
C3H/HeJ ENSMUSG00175003629
 protein coding gene Chr11:40684909-40812111 (-)
C57BL/6NJ ENSMUSG00215008561
 protein coding gene Chr11:40605648-40732314 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016229
 protein coding gene Chr11:38989611-39116195 (-)
CAST/EiJ ENSTCUG00005012959
 protein coding gene Chr11:40413979-40544254 (-)
CBA/J ENSMUSG00210006505
 protein coding gene Chr11:40574121-40701323 (-)
DBA/2J ENSMUSG00185009982
 protein coding gene Chr11:40761566-40891100 (-)
FVB/NJ ENSMUSG00205011441
 protein coding gene Chr11:40693602-40820397 (-)
JF1/MsJ ENSUMUG00000021078
 protein coding gene Chr11:40974148-41102064 (-)
LP/J ENSMUSG00230029129
 protein coding gene Chr11:41903277-42030461 (-)
NOD/ShiLtJ ENSMUSG00190007306
 protein coding gene Chr11:40791982-40919192 (-)
NZO/HlLtJ ENSMUSG00225035265
 protein coding gene Chr11:43855675-43985153 (-)
PWK/PhJ ENSLUMG00010007211
 protein coding gene Chr11:40566066-40693215 (-)
SPRET/EiJ ENSMSPG00010002203
 protein coding gene Chr11:41149953-41210830 (-)
WSB/EiJ ENSIUOG00005002034
 protein coding gene Chr11:40550573-40677169 (-)



Homology
more
  • Human Ortholog
    ADRA1B, adrenoceptor alpha 1B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADRA1B, adrenoceptor alpha 1B
  • Synonyms
    ADRA1, ALPHA1BAR
  • Links
    NCBI Gene ID: 147
    UniProt: P35368

  • Chr Location
    5q33.3; chr5:159865080-159989205 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    44 phenotypes from 1 allele in 3 genetic backgrounds
    17 phenotypes from multigenic genotypes
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted mutations that inactivate the gene affect atrial contractility and left ventricle function, suggesting their use in modeling chronic heart failure in humans.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    68
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    680
  • Tissues
    54
  • cDNA Data
    13
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000050541 Ensembl Gene Model | MGI Sequence Detail 126605 C57BL/6J ±  kb
    transcript ENSMUST00000067258 Ensembl | MGI Sequence Detail 3331 Not Applicable  
    polypeptide ENSMUSP00000070200 Ensembl | MGI Sequence Detail 515 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 3
      cDNA 14
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-28066
    References
    more
    • Summaries
      All 115
      Developmental Gene Expression 7
      Gene Ontology 19
      Phenotypes 38
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:362274 Silva A, et al., Liver adrenoceptor alpha-1b plays a key role in energy and glucose homeostasis in female mice. Am J Physiol Endocrinol Metab. 2024 Nov 1;327(5):E626-E635
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory