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Fkbp10 Gene Detail
Summary
  • Symbol
    Fkbp10
  • Name
    FK506 binding protein 10
  • Synonyms
    65kDa, Fkbp1-rs, Fkbp6, FKBP65, Fkbp-rs1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104769
    NCBI Gene: 14230
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:100306523-100315650 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 63.47 cM
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    86 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104769
 protein coding gene Chr11:100306520-100315666 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019154
 protein coding gene Chr11:103174052-103184516 (+)
A/J MGP_AJ_G0019122
 protein coding gene Chr11:98863492-98873981 (+)
AKR/J MGP_AKRJ_G0019091
 protein coding gene Chr11:101911462-101920145 (+)
BALB/cJ MGP_BALBcJ_G0019096
 protein coding gene Chr11:99343925-99353038 (+)
C3H/HeJ MGP_C3HHeJ_G0018905
 protein coding gene Chr11:102107715-102119591 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019545
 protein coding gene Chr11:106379715-106392793 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017171
 protein coding gene Chr11:96280943-96290019 (+)
CAST/EiJ MGP_CASTEiJ_G0018459
 protein coding gene Chr11:103079825-103089649 (+)
CBA/J MGP_CBAJ_G0018874
 protein coding gene Chr11:110805799-110814906 (+)
DBA/2J MGP_DBA2J_G0018986
 protein coding gene Chr11:98401930-98411322 (+)
FVB/NJ MGP_FVBNJ_G0018976
 protein coding gene Chr11:97933349-97943100 (+)
LP/J MGP_LPJ_G0019055
 protein coding gene Chr11:103719113-103731016 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019007
 protein coding gene Chr11:110418155-110428876 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019583
 protein coding gene Chr11:102254699-102264485 (+)
PWK/PhJ MGP_PWKPhJ_G0018222
 protein coding gene Chr11:99439339-99449814 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018014
 protein coding gene Chr11:101971037-101984825 (+)
WSB/EiJ MGP_WSBEiJ_G0018508
 protein coding gene Chr11:102239446-102249166 (+)



Homology
more
  • Human Ortholog
    FKBP10, FKBP prolyl isomerase 10
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FKBP10, FKBP prolyl isomerase 10
  • Synonyms
    BRKS, BRKS1, FKBP65, hFKBP65, OI11, OI6, PPIASE, TLH1
  • Links
    NCBI Gene ID: 60681
    neXtProt AC: NX_Q96AY3
    UniProt: Q96AY3

  • Chr Location
    17q21.2; chr17:41812680-41823213 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human FKBP10 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 2 genetic backgrounds
    3 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice do not survive birth, and embryos exhibit delayed growth, tissue fragility, decreased aorta wall thickness, craniofacial and forelimb anomalies, and connective tissue alterations. Mutant MEFs retain procollagen in the cell layer and show dilated endoplasmic reticulum.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    743
  • Tissues
    28
  • cDNA Data
    107
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001555 Ensembl Gene Model | MGI Sequence Detail 9128 C57BL/6J ±  kb
    transcript ENSMUST00000001595 Ensembl | MGI Sequence Detail 2584 Not Applicable  
    polypeptide ENSMUSP00000001595 Ensembl | MGI Sequence Detail 581 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 108
      cDNA 107
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-28060, MGD-MRK-9809, MGI:2144131, MGI:95540
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 3
      Gene Ontology 10
      Phenotypes 22
    • Earliest
      J:15604 Simek SL, et al., Sequence and localization of a novel FK506-binding protein to mouse chromosome 11. Genomics. 1993 Nov;18(2):407-9
    • Latest
      J:335783 Lim J, et al., Localized chondro-ossification underlies joint dysfunction and motor deficits in the Fkbp10 mouse model of osteogenesis imperfecta. Proc Natl Acad Sci U S A. 2021 Jun 22;118(25):e2100690118
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory