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Fdft1 Gene Detail
Summary
  • Symbol
    Fdft1
  • Name
    farnesyl diphosphate farnesyl transferase 1
  • Synonyms
    SQS, squalene synthase, Ss
  • Feature Type
    protein coding gene
  • IDs
    MGI:102706
    NCBI Gene: 14137
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:63382599-63417027 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 33.24 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    926 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102706
 protein coding gene Chr14:63382599-63419136 (-)
129S1/SvImJ ENSMUSG00200028562
 protein coding gene Chr14:51984067-52018515 (-)
A/J ENSMUSG00195029367
 protein coding gene Chr14:52164827-52199267 (-)
AKR/J ENSMUSG00220027532
 protein coding gene Chr14:51512258-51546693 (-)
BALB/cJ ENSMUSG00180031973
 protein coding gene Chr14:51786719-51821156 (-)
C3H/HeJ ENSMUSG00175030692
 protein coding gene Chr14:53519887-53554332 (-)
C57BL/6NJ ENSMUSG00215024086
 protein coding gene Chr14:51710283-51744734 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019401
 protein coding gene Chr14:54303494-54333563 (-)
CAST/EiJ ENSTCUG00005037354
 protein coding gene Chr14:53450370-53484904 (-)
CBA/J ENSMUSG00210032982
 protein coding gene Chr14:52152743-52187178 (-)
DBA/2J ENSMUSG00185029075
 protein coding gene Chr14:57317691-57352136 (-)
FVB/NJ ENSMUSG00205019571
 protein coding gene Chr14:51670204-51704641 (-)
JF1/MsJ ENSUMUG00000029471
 protein coding gene Chr14:68513177-68547659 (-)
LP/J ENSMUSG00230032764
 protein coding gene Chr14:69347252-69381696 (-)
NOD/ShiLtJ ENSMUSG00190039368
 protein coding gene Chr14:51947435-51981872 (-)
NZO/HlLtJ ENSMUSG00225046101
 protein coding gene Chr14:59689574-59724002 (-)
PWK/PhJ ENSLUMG00010031116
 protein coding gene Chr14:51396606-51431080 (-)
SPRET/EiJ ENSMSPG00010032275
 protein coding gene Chr14:54886134-54915585 (-)
WSB/EiJ ENSIUOG00005037069
 protein coding gene Chr14:51393741-51428179 (-)



Homology
more
  • Human Ortholog
    FDFT1, farnesyl-diphosphate farnesyltransferase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FDFT1, farnesyl-diphosphate farnesyltransferase 1
  • Synonyms
    DGPT, ERG9, SQS, SQSD, SS
  • Links
    NCBI Gene ID: 2222
    UniProt: P37268

  • Chr Location
    8p23.1; chr8:11795570-11839500 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 3 alleles in 3 genetic backgrounds
    1 images
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation die around E9.5-10.5. Conditional homozygous null in which the gene is deleted specifically in oligodendrocyte and Schwann cell display dysmyelination of spinal cord and brain white matter, and showed ataxia and tremor.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    942
  • Tissues
    138
  • cDNA Data
    109
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021273 Ensembl Gene Model | MGI Sequence Detail 34429 C57BL/6J ±  kb
    transcript ENSMUST00000238526 Ensembl | MGI Sequence Detail 3048 Not Applicable  
    polypeptide ENSMUSP00000158805 Ensembl | MGI Sequence Detail 460 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 115
      cDNA 111
      Primer pair 3
      Other 1
      Antibodies 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-19610
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 9
      Gene Ontology 14
      Phenotypes 25
    • Earliest
      J:371708 Bruenger E, et al., Determination of isopentenyl diphosphate and farnesyl diphosphate in tissue samples with a comment on secondary regulation of polyisoprenoid biosynthesis. Anal Biochem. 1988 Sep;173(2):321-7
    • Latest
      J:359200 Kaji S, et al., Apolipoprotein E aggregation in microglia initiates Alzheimer's disease pathology by seeding beta-amyloidosis. Immunity. 2024 Oct 9;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory