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Kiss1tm1.1(cre/EGFP)Rpa - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Kiss1tm1.1(cre/EGFP)Rpa
KiSS-1 metastasis-suppressor; targeted mutation 1.1, Richard D Palmiter 		Driver: Kiss1
Type: Targeted (Null/knockout, Recombinase, Reporter)
Synonym: Kiss1Cre:GFP, Kiss1Cre (v2)
Molecular description: The targeting construct contains a Cre:GFP fusion carrying Myc 3' UTR pA, and an FRT-SvNeo-FRT cassette introduced to the end of the first exon, such that the sequence between the start codon and the end of that exon are deleted. Flp-mediated recombination removed the FRT-flanked neo cassette. The construct removes the nuclear localization signal from cre, uses a non-optimal initiation codon, removes part of the N-terminal sequence of cre, adds a 3' untranslated region from the Myc gene that promotes a short mRNA half-life, and deletes part of exon 1 that includes the signal peptide.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Kiss1tm1.1(cre/EGFP)Rpa activity also observed in:
head
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:270342 Fig. 2 J:270342 Fig. S1 J:270342 Fig. S2
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 8 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory