probe 7 Probe Detail MGI Mouse MGI:12293

probe 7 Probe Detail

Name

probe 7
Sequence Type

genomic
ID

MGI:12293
Region Covered

encodes the H-2Ea exons 2-4
Parent Clone

cosmid 32.1
Vector Type

Plasmid
Insert Site

SalI
Insert Size

3.4 kb

Species

mouse, laboratory
Strain

BALB/c
Tissue

sperm

H2-Ea

histocompatibility 2, class II antigen E alpha

J:6885 Steinmetz M, et al., Nature. 1982 Nov 4;300(5887):35-42

Endonuclease	Gene	Allele	Fragments	Strains
EcoRI	H2-Ea	b	8.6,3kb	B10.A-H2ⁱ³/(3R), C3H
EcoRI	H2-Ea	c	8.2,3kb	A.SW-H2^s/Sn, B10.M-H2^ap1/(11R), B10.Q-H2^q/SgJ, BALB/c, C57BL/6
HpaI	H2-Ea	b	18,4.4kb	B10.A-H2ⁱ³/(3R), C3H
HpaI	H2-Ea	c	9.8,4.4kb	A.SW-H2^s/Sn, BALB/c, C57BL/6

J:7253 Shin HS, et al., Nature. 1983 Nov 24-30;306(5941):380-3

Notes: Strains and/or t haplotype designations appear in the allele groupings.

Endonuclease	Gene	Allele	Fragments	Strains
HindIII	H2-Ea	a	9.0kb	C3.t^w12, STOCK t^K115, STOCK t^K120, STOCK t^K130, STOCK t^S510, STOCK t^S735
		b	8.1kb	STOCK t^K100, STOCK t^w32
		c	8.4kb	C3H

J:7675 Shin HS, et al., Cell. 1984 Dec;39(3 Pt 2):573-8

Notes: Strain and/or t haplotype designations appear in the allele groupings.

Endonuclease	Gene	Allele	Fragments	Strains
HindIII	H2-Ea	a	9.0kb	C3H-T/t^w12
HindIII	H2-Ea	b	8.1kb	C3.t¹², STOCK t^w32
PstI	H2-Ea	a	2.7kb	C3.t¹², STOCK t^w32
PstI	H2-Ea	b	3.0kb	C3.t^w5

J:15532 Steinmetz M, et al., EMBO J. 1984 Dec 1;3(12):2995-3003

Endonuclease	Gene	Allele	Fragments	Strains
BamHI	H2-Ea	a	6.6kb	A.SW-H2^s/Sn, B10.DRB62, B10.KPA44, B10.STA10, B10.STA62, BALB/c, C3H, C57BL/6
BamHI	H2-Ea	b	6.6,5.8kb	B10.CAS2
EcoRI	H2-Ea	a	8.2,3.0kb	A.SW-H2^s/Sn, B10.DRB62, B10.KPA44, B10.STA62, BALB/c, C57BL/6
		b	8.6,3.0kb	C3H
		c	7.5,3.0kb	B10.STA10
		d	7.8,3.0kb	B10.CAS2
HindIII	H2-Ea	a	9.0kb	A.SW-H2^s/Sn, B10.KPA44, B10.STA10, B10.STA62, BALB/c, C3H, C57BL/6
		b	8.0kb	B10.CAS2
		c	8.6kb	B10.DRB62
KpnI	H2-Ea	a	8.8,4.2kb	B10.DRB62, B10.KPA44, B10.STA10, B10.STA62, BALB/c, C3H
KpnI	H2-Ea	b	8.8,3.5kb	A.SW-H2^s/Sn, B10.CAS2, C57BL/6

J:8530 Lafuse WP, et al., Immunogenetics. 1986;24(6):352-60

Endonuclease	Gene	Allele	Fragments	Strains
DraI	H2-Ea	a	7.2kb	B10.K-H2^k, B10.RSB5, B10.RSB6, B10.RSB8, B10.RSB11, B10.RSB12, B10.RSB14, B10.RSB15, B10.S-H2^t4/(9R)/J, B10.TL-H2^r1
DraI	H2-Ea	b	4.4kb	B10.F-H2^pb1/(13R)J, B10.P-H2^p, B10.RPD1, B10.RPD2
PstI	H2-Ea	a	6.2,2.7kb	B10.F-H2^pb1/(13R)J, B10.P-H2^p
		b	6.2,3.3kb	B10.RSB6, B10.RSB8, B10.RSB11, B10.RSB12, B10.RSB15
		c	5.8,3.3kb	B10.K-H2^k, B10.RSB5, B10.RSB14, B10.S-H2^t4/(9R)/J, B10.TL-H2^r1
		d	5.8,2.7kb	B10.RPD1, B10.RPD2

J:20297 Lafuse WP, et al., J Exp Med. 1986 Jun 1;163(6):1518-28

Endonuclease	Gene	Allele	Fragments	Strains
HapI	H2-Ea	a	18,4.4kb	B10.K-H2^k, B10.RSB5, B10.RSB6, B10.RSB8, B10.RSB11, B10.RSB12, B10.RSB14, B10.RSB15, B10.S-H2^t4/(9R)/J, B10.TL-H2^r1
HapI	H2-Ea	b	9.8,4.4kb	B10.F-H2^pb1/(13R)J, B10.P-H2^p
HpaI	H2-Ea	a	18,4.4kb	B10.K-H2^k
HpaI	H2-Ea	b	9.8,4.4kb	B10.P-H2^p, B10.RPD1, B10.RPD2
RsaI	H2-Ea	a	2.0,1.7,1.0kb	B10.K-H2^k, B10.RPD1, B10.RPD2, B10.RSB5, B10.RSB14, B10.S-H2^t4/(9R)/J, B10.TL-H2^r1
RsaI	H2-Ea	b	2.8,1.7,1.0kb	B10.F-H2^pb1/(13R)J, B10.P-H2^p, B10.RSB6, B10.RSB8, B10.RSB11, B10.RSB12, B10.RSB15, B10.S-H2^t4/(9R)/J, B10.TL-H2^r1
SacI	H2-Ea	a	20,1.7kb	B10.K-H2^k
SacI	H2-Ea	b	15,1.7kb	B10.P-H2^p, B10.RPD1, B10.RPD2
SacI	H2-Ea	a	~20,~1.7kb	B10.K-H2^k, B10.RSB5, B10.RSB6, B10.RSB8, B10.RSB11, B10.RSB12, B10.RSB14, B10.RSB15, B10.S-H2^t4/(9R)/J, B10.TL-H2^r1
SacI	H2-Ea	b	~15,~1.7kb	B10.F-H2^pb1/(13R)J, B10.P-H2^p

J:6885 Steinmetz M, et al., A molecular map of the immune response region from the major histocompatibility complex of the mouse. Nature. 1982 Nov 4;300(5887):35-42

J:20091 McNicholas J, et al., DNA sequence of the gene encoding the E alpha Ia polypeptide of the BALB/c mouse. Science. 1982 Dec 17;218(4578):1229-32

J:7253 Shin HS, et al., Inversion in the H-2 complex of t-haplotypes in mice. Nature. 1983 Nov 24-30;306(5941):380-3

J:7675 Shin HS, et al., Gene mapping within the T/t complex of the mouse. IV: The inverted MHC is intermingled with several t-lethal genes. Cell. 1984 Dec;39(3 Pt 2):573-8

J:15532 Steinmetz M, et al., Tracts of high or low sequence divergence in the mouse major histocompatibility complex. EMBO J. 1984 Dec 1;3(12):2995-3003

J:8530 Lafuse WP, et al., Recombination hot spots within the I region of the mouse H-2 complex map to the E beta and E alpha genes. Immunogenetics. 1986;24(6):352-60

J:20297 Lafuse WP, et al., Mapping of a second recombination hot spot within the I-E region of the mouse H-2 gene complex. J Exp Med. 1986 Jun 1;163(6):1518-28

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24