Otc Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Otc
ornithine transcarbamylase
MGI:97448

27 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Acads^del-J/Acads⁺ Otc^spf/Y involves: BALB/cByJ * CD-1	aciduria	J:4165
Acads^del-J/Acads⁺ Otc^spf/Y involves: BALB/cByJ * CD-1	oroticaciduria	J:4165
Acads^del-J/Acads^del-J Otc^spf/Y involves: BALB/cByJ * CD-1	aciduria	J:4165
	premature death	J:4165
	sparse hair	J:4165
Acads^del-J/Acads^del-J Otc^spf/Otc⁺ involves: BALB/cByJ * CD-1	aciduria	J:4165
Acads^del-J/Acads^del-J Otc^spf/Otc^spf involves: BALB/cByJ * CD-1	oroticaciduria	J:4165
	premature death	J:4165
B2m^tm1Jae/B2m^tm1Jae Foxp3^sf Otc^spf/Y involves: 129/Rl * 129S2/SvPas	abnormal immune system organ morphology	J:20865
	abnormal interleukin level	J:20865
	abnormal lymph node morphology	J:20865
	abnormal tumor necrosis factor level	J:20865
	anemia	J:20865
	decreased body size	J:20865
	decreased hematocrit	J:20865
	dermatitis	J:20865
	enlarged lymph nodes	J:20865
	enlarged spleen	J:20865
	increased CD4-positive, alpha-beta T cell number	J:20865
	increased IgG level	J:20865
	increased IgM level	J:20865
	increased immunoglobulin level	J:20865
	increased plasma cell number	J:20865
Cd4^tm1Litt/Cd4^tm1Litt Foxp3^sf Otc^spf/Y involves: 129/Rl * 129S2/SvPas	abnormal CD8-positive, alpha beta T cell morphology	J:20865
	abnormal cytokine secretion	J:20865
	abnormal immune system organ morphology	J:20865
	enlarged lymph nodes	J:20865
	increased IgG level	J:20865
	increased IgM level	J:20865
	increased interleukin-4 secretion	J:20865
	increased interleukin-6 secretion	J:20865
	increased tumor necrosis factor secretion	J:20865
	premature death	J:20865
Foxp3^sf Otc^spf/Y involves: 129/Rl	anemia	J:20865
	decreased body weight	J:20865
	decreased hematocrit	J:20865
	enlarged lymph nodes	J:20865
	enlarged spleen	J:20865
	increased CD4-positive, alpha-beta T cell number	J:20865
	postnatal lethality, incomplete penetrance	J:20865
	premature death	J:20865
	skin lesions	J:20865

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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