Ascl1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ascl1
achaete-scute family bHLH transcription factor 1
MGI:96919

30 phenotypes from 4 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ascl1^{tm1.1(cre/ERT2)Jejo}/Ascl1⁺ involves: 129S6/SvEvTac	no abnormal phenotype detected	J:171439
Ascl1^{tm1.1(cre/ERT2)Jejo}/Ascl1^{tm1.1(cre/ERT2)Jejo} involves: 129S6/SvEvTac * C57BL/6 * ICR	abnormal nervous system development	J:178291
	neonatal lethality, complete penetrance	J:178291
Ascl1^tm1And/Ascl1⁺ involves: 129	decreased number of pulmonary neuroendocrine bodies	J:64088
Ascl1^tm1And/Ascl1⁺ involves: 129	decreased solitary pulmonary neuroendocrine cell number	J:64088
Ascl1^tm1And/Ascl1^tm1And involves: 129	abnormal dorsal interneuron 2 morphology	J:98830
	abnormal dorsal interneuron 3 morphology	J:98830
	abnormal dorsal interneuron 4 morphology	J:98830
	abnormal dorsal interneuron 5 morphology	J:98830
	abnormal dorsal interneuron 6 morphology	J:98830
	abnormal dorsal interneuron morphology	J:98830
	abnormal lung development	J:113000
	abnormal neuron apoptosis	J:109482
	abnormal telencephalon development	J:74525
	abnormal ventral interneuron 2 morphology	J:74525
	absent pulmonary neuroendocrine bodies	J:64088, J:113000
	absent solitary pulmonary neuroendocrine cells	J:64088, J:113000
	decreased neuronal precursor proliferation	J:203419
	impaired neuron differentiation	J:203419
Ascl1^tm1And/Ascl1^tm1And involves: 129S1/Sv * 129X1/SvJ	neonatal lethality, complete penetrance	J:15850
Ascl1^tm1And/Ascl1^tm1And involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal enteric neuron morphology	J:15850
	abnormal olfactory epithelium morphology	J:15850
	abnormal olfactory sensory neuron morphology	J:15850
	abnormal parasympathetic ganglion morphology	J:15850
	abnormal skin pigmentation	J:15850
	abnormal sympathetic ganglion morphology	J:15850
	absent enteric neurons	J:15850
	absent gastric milk in neonates	J:15850
	neonatal lethality, complete penetrance	J:15850
	respiratory distress	J:15850
Ascl1^tm1Cbm/Ascl1^tm1Cbm involves: 129P2/OlaHsd	abnormal horizontal basal cell of olfactory epithelium morphology	J:173538
Ascl1^tm2Fgu/Ascl1^tm2Fgu Not Specified	abnormal neuronal migration	J:174732

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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