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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Gjb2
gap junction protein, beta 2
MGI:95720
50 phenotypes from 7 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gjb2tm1Kkam/Gjb2tm1Kkam
Tg(Mpz-cre)94Imeg/0
involves: 129S4/SvJae * C57BL/6J 		abnormal cochlea morphology J:209627
abnormal ear physiology J:209627
abnormal plasma membrane morphology J:209627
increased or absent threshold for auditory brainstem response J:209627
sensorineural hearing loss J:209627
Gjb2tm1Kwi/Gjb2tm1Kwi
involves: 129P2/OlaHsd * C57BL/6 		abnormal placenta development J:46665
abnormal placental labyrinth vasculature morphology J:46665
abnormal placental transport J:46665
decreased embryo size J:46665
decreased placental labyrinth size J:46665
embryonic lethality during organogenesis, complete penetrance J:46665
Gjb2tm1Mony/Gjb2tm1Mony
involves: 129S1/Sv * 129X1/SvJ 		decreased fetal size J:89907
embryonic growth retardation J:89907
fetal growth retardation J:89907
prenatal lethality, complete penetrance J:89907
Gjb2tm1Ugds/Gjb2tm1Ugds
Tg(Otog-cre)1Ugds/0
involves: 129P2/OlaHsd * C57BL/6 		abnormal cochlear endolymph ionic homeostasis J:77823
abnormal cochlear inner hair cell morphology J:77823
abnormal inner hair cell synaptic ribbon morphology J:77823
abnormal interdental cell morphology J:77823
cochlear degeneration J:77823
cochlear outer hair cell degeneration J:77823
decreased endocochlear potential J:77823
degeneration of organ of Corti supporting cells J:77823
increased or absent threshold for auditory brainstem response J:77823
organ of Corti degeneration J:77823
sensorineural hearing loss J:77823
Gjb2tm1Ugds/Gjb2tm1Ugds
Tg(Sox10-cre)1Wdr/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		cochlear ganglion degeneration J:206835
cochlear hair cell degeneration J:206835
deafness J:206835
degeneration of organ of Corti supporting cells J:206835
organ of Corti degeneration J:206835
Gjb2tm1Ugds/Gjb2tm1Ugds
Tg(Sox10-cre)1Wdr/0
involves: 129S2/SvPasCrl * C57BL/6 * CBA 		abnormal hair cell physiology J:178055
Gjb2tm2.2Kwi/Gjb2+
Tg(Pgk1-cre)1Lni/0
involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6 		abnormal nail morphology J:166732
abnormal skin morphology J:166732
abnormal tail morphology J:166732
decreased body size J:166732
decreased endocochlear potential J:166732
epidermal hyperplasia J:166732
female infertility J:166732
hyperkeratosis J:166732
impaired hearing J:166732
impaired skin barrier function J:166732
increased keratinocyte proliferation J:166732
increased or absent threshold for auditory brainstem response J:166732
postnatal lethality, incomplete penetrance J:166732
prenatal lethality, incomplete penetrance J:166732
scaly skin J:166732
shiny skin J:166732
short tail J:166732
thick epidermis J:166732
normal vision/eye phenotype J:166732
Gjb2tm3(Gjb1)Kwi/Gjb2+
involves: 129P2/OlaHsd 		no abnormal phenotype detected J:188626
Gjb2tm3.1(Gjb1)Kwi/Gjb2+
Tg(Prrx1-cre)1Cjt/0
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL * SJL/J 		no abnormal phenotype detected J:188626
Gjb2tm3.1(Gjb1)Kwi/Gjb2+
Tg(Tek-cre)1Arnd/0
involves: 129P2/OlaHsd * C57BL/6 * CBA * DBA/2 * SJL 		no abnormal phenotype detected J:188626
Gjb2tm3.1(Gjb1)Kwi/Gjb2+
Tg(KRT5-cre)5132Jlj/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2J * SJL 		abnormal lymphatic vessel morphology J:188626
absent mandible J:188626
lethality throughout fetal growth and development, complete penetrance J:188626
lymphedema J:188626
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory