Gfpt1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gfpt1
glutamine fructose-6-phosphate transaminase 1
MGI:95698

25 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gfpt1^{tm1b(EUCOMM)Wtsi}/Gfpt1⁺ C57BL/6N-Gfpt1^{tm1b(EUCOMM)Wtsi}/H	increased circulating cholesterol level	J:211773
	increased circulating HDL cholesterol level	J:211773
	persistence of hyaloid vascular system	J:211773
Gfpt1^{tm1b(EUCOMM)Wtsi}/Gfpt1^{tm1b(EUCOMM)Wtsi} C57BL/6N-Gfpt1^{tm1b(EUCOMM)Wtsi}/H	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773
Gfpt1^{tm1c(EUCOMM)Wtsi}/Gfpt1^{tm1c(EUCOMM)Wtsi} Tg(Ckmm-cre)5Khn/0 involves: C57BL/6J * C57BL/6N * SJL/J	abnormal muscle electrophysiology	J:265013
	abnormal myelin sheath morphology	J:265013
	abnormal neuromuscular synapse morphology	J:265013
	abnormal sarcolemma morphology	J:265013
	abnormal sarcoplasmic reticulum morphology	J:265013
	abnormal skeletal muscle fiber morphology	J:265013
	centrally nucleated skeletal muscle fibers	J:265013
	decreased grip strength	J:265013
	decreased myelin sheath thickness	J:265013
	decreased skeletal muscle fiber size	J:265013
	normal growth/size/body region phenotype	J:265013
	impaired skeletal muscle contractility	J:265013
	increased muscle fatigability	J:265013
	increased skeletal muscle fiber size	J:265013
	increased variability of skeletal muscle fiber size	J:265013
	normal muscle phenotype	J:265013
	muscle weakness	J:265013
	myopathy	J:265013
	skeletal muscle fiber atrophy	J:265013
	skeletal muscle fiber necrosis	J:265013

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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