Gch1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gch1
GTP cyclohydrolase 1
MGI:95675

23 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gch1^em1(IMPC)H/Gch1^em1(IMPC)H C57BL/6NTac-Gch1^em1(IMPC)H/H	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773
Gch1^em1Ypt/Gch1^em1Ypt C57BL/6-Gch1^em1Ypt	abnormal brain morphology	J:295169
	abnormal liver morphology	J:295169
	abnormal motor capabilities/coordination/movement	J:295169
	abnormal posture	J:295169
	decreased body weight	J:295169
	decreased brain tyrosine 3-monooxygenase activity	J:295169
	decreased locomotor activity	J:295169
	decreased nervous system dopamine level	J:295169
	decreased noradrenaline level	J:295169
	decreased serotonin level	J:295169
	decreased vocalization	J:295169
	impaired righting response	J:295169
	increased phenylalanine level	J:295169
	limb grasping	J:295169
	postnatal growth retardation	J:295169
	postnatal lethality, complete penetrance	J:295169
	prenatal lethality prior to heart atrial septation	J:295169
	slow postnatal weight gain	J:295169
Gch1^tm1.2Drg/Gch1^tm1.2Drg involves: C57BL/6J	decreased dopamine level	J:219813
	decreased heart rate	J:219813
	embryonic lethality during organogenesis, complete penetrance	J:219813

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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