Gch1^tm1.2Drg
Targeted Allele Detail

Summary

• Symbol: Gch1^tm1.2Drg
• Name: GTP cyclohydrolase 1; targeted mutation 1.2, David Greaves
• MGI ID: MGI:5708509
• Gene: Gch1 Location: Chr14:47391352-47426870 bp, - strand Genetic Position: Chr14, 24.6 cM, cytoband C2-3
• Alliance: Gch1^tm1.2Drg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:219813
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 that encode for the GTPCH active site were flanked by loxP sites and an FRT flanked neo cassette was inserted in intron 2. Recombinase mediated recombination removed the neo cassette and exons 2 and 3. (J:219813)

Expression

In Mice Carrying this Mutation:	11 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gch1 Mutation: 15 strains or lines available

References

• Original: J:219813 Douglas G, et al., A requirement for Gch1 and tetrahydrobiopterin in embryonic development. Dev Biol. 2015 Mar 1;399(1):129-38
• All: 1 reference(s)