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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Fah
fumarylacetoacetate hydrolase
MGI:95482
63 phenotypes from 5 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Fah1R/Fah1R
involves: BALB/cRl * C3H/Rl * C57BL/10Rl
abnormal urine homeostasis J:54592
neonatal lethality, complete penetrance J:54592
Fah2R/Fah2R
involves: BALB/cRl
abnormal urine homeostasis J:54592
postnatal lethality, complete penetrance J:54592
Fahem1(IMPC)Mbp/Fah+
C57BL/6N-Fahem1(IMPC)Mbp/MbpMmucd
abnormal heart morphology J:211773
abnormal kidney morphology J:211773
abnormal liver morphology J:211773
abnormal placenta morphology J:211773
abnormal placenta vasculature J:211773
abnormal retina blood vessel morphology J:211773
abnormal retina vasculature morphology J:211773
abnormal skin morphology J:211773
abnormal spleen morphology J:211773
abnormal testis morphology J:211773
embryonic growth retardation J:211773
enlarged heart J:211773
enlarged kidney J:211773
enlarged spleen J:211773
enlarged testis J:211773
persistence of hyaloid vascular system J:211773
small kidney J:211773
small liver J:211773
Fahem1(IMPC)Mbp/Fahem1(IMPC)Mbp
C57BL/6N-Fahem1(IMPC)Mbp/MbpMmucd
abnormal blood vessel morphology J:211773
abnormal placenta morphology J:211773
abnormal placenta vasculature J:211773
edema J:211773
preweaning lethality, complete penetrance J:211773
Fahswst/Fahswst
C57BL/6J-Fahswst/Nwu
abnormal sleep pattern J:98867
Fahtm1Mgo/Fahtm1Mgo
either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)
abnormal circulating aspartate transaminase level J:16046
hypoglycemia J:16046
increased circulating creatinine level J:16046
neonatal lethality, complete penetrance J:16046
Fahtm1Mgo/Fahtm1Mgo
involves: 129S7/SvEvBrd
decreased hepatocyte apoptosis J:105440
increased susceptibility to xenobiotic induced morbidity/mortality J:105440
liver failure J:105440
Fahtm1Mgo/Fahtm1Mgo
involves: 129S7/SvEvBrd * C57BL
abnormal amino acid level J:27735
abnormal circulating amino acid level J:27735
abnormal hepatocyte mitochondrial morphology J:27735
abnormal hepatocyte morphology J:27735
abnormal hepatocyte physiology J:27735
abnormal liver lobule morphology J:27735
aminoaciduria J:27735
enlarged kidney J:27735
increased alpha-fetoprotein level J:27735
increased circulating aspartate transaminase level J:27735
increased circulating bilirubin level J:27735
increased circulating tyrosine level J:27735
increased hepatocellular carcinoma incidence J:27735
increased hepatoma incidence J:27735
increased liver adenoma incidence J:27735
increased liver tumor incidence J:27735
increased pancreatic alpha cell number J:27735
kidney degeneration J:27735
liver inflammation J:27735
normal liver/biliary system phenotype J:27735
neonatal lethality, complete penetrance J:27735
pale kidney J:27735
pancreas hyperplasia J:27735
Fahtm1Mgo/Fahtm1Mgo
involves: 129S7/SvEvBrd * C57BL/6
abnormal hepatocyte morphology J:138701
abnormal liver physiology J:138701
abnormal liver regeneration J:138701
aminoaciduria J:138701
decreased hepatocyte proliferation J:138701
enlarged kidney J:138701
impaired liver regeneration J:138701
increased hepatocellular carcinoma incidence J:138701
increased susceptibility to induced morbidity/mortality J:138701
increased susceptibility to injury J:138701
weight loss J:138701
Fahtm1Mgo/Fahtm1Mgo
involves: 129S7/SvEvBrd * PT
abnormal liver physiology J:77295
dilated renal tubule J:77295
increased circulating tyrosine level J:77295
jaundice J:77295
kidney inflammation J:77295
pale liver J:77295
weight loss J:77295

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory