78 phenotypes from 6 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Destm1.1Ccrs/Des+ involves: 129 * C57BL/6J	abnormal heart electrocardiography waveform feature	J:219616
	abnormal impulse conducting system conduction	J:219616
	abnormal P wave	J:219616
	abnormal skeletal muscle fiber morphology	J:219616
	atrial fibrillation	J:219616
	atrioventricular block	J:219616
	cardiac fibrosis	J:219616
	cardiomyopathy	J:219616
	decreased cardiac muscle contractility	J:219616
	dilated cardiomyopathy	J:219616
	irregular heartbeat	J:219616
	normal muscle phenotype	J:219616
	prolonged HV interval	J:219616
	sinoatrial block	J:219616
	ventricular premature beat	J:219616
	ventricular tachycardia	J:219616
Destm1.1Ccrs/Destm1.1Ccrs involves: 129 * C57BL/6J	abnormal heart electrocardiography waveform feature	J:219616
	abnormal impulse conducting system conduction	J:219616
	abnormal skeletal muscle fiber mitochondrial morphology	J:219616
	abnormal skeletal muscle fiber morphology	J:219616
	abnormal soleus morphology	J:219616
	abnormal Z line morphology	J:219616
	atrial fibrillation	J:219616
	atrioventricular block	J:219616
	cardiac fibrosis	J:219616
	cardiomyopathy	J:219616
	centrally nucleated skeletal muscle fibers	J:219616
	decreased cardiac muscle contractility	J:219616
	decreased cardiac stroke volume	J:219616
	decreased grip strength	J:219616
	dilated cardiomyopathy	J:219616
	dystrophic muscle	J:219616
	impaired skeletal muscle contractility	J:219616
	increased mitochondrial size	J:219616
	increased variability of skeletal muscle fiber size	J:219616
	irregular heartbeat	J:219616
	myopathy	J:219616
	progressive muscle weakness	J:219616
	prolonged HV interval	J:219616
	sinoatrial block	J:219616
	skeletal muscle degeneration	J:219616
	skeletal muscle endomysial fibrosis	J:219616
	skeletal muscle fiber degeneration	J:219616
	ventricular premature beat	J:219616
	ventricular tachycardia	J:219616
Destm1Cap/Destm1Cap involves: 129S7/SvEvBrd	abnormal cardiovascular system physiology	J:88267
	abnormal heart morphology	J:88267
	abnormal myocardial fiber morphology	J:88267
	abnormal myocardial fiber physiology	J:88267
	cardiac fibrosis	J:88267
	cardiac hypertrophy	J:88267
	decreased ventricle muscle contractility	J:88267
	dilated cardiomyopathy	J:88267
	dystrophic cardiac calcinosis	J:88267
Destm1Cap/Destm1Cap involves: 129S7/SvEvBrd * C57BL/6	abnormal cardiac muscle relaxation	J:59831
	abnormal myocardial fiber morphology	J:35123, J:59831
	abnormal myocardium layer morphology	J:35123
	abnormal skeletal muscle morphology	J:35123
	abnormal smooth muscle morphology	J:35123
	cardiac hypertrophy	J:59831
	cardiac interstitial fibrosis	J:35123
	cardiomyopathy	J:35123
	congestive heart failure	J:59831
	decreased ventricle muscle contractility	J:59831
	dilated heart left ventricle	J:59831
	dilated heart right ventricle	J:59831
	disorganized myocardium	J:35123, J:59831
	dystrophic cardiac calcinosis	J:35123, J:59831
	enlarged heart	J:59831
	impaired exercise endurance	J:59831
	lethargy	J:35123
	muscle degeneration	J:35123
	premature death	J:59831
	thin myocardium	J:59831
Destm1Cba/Destm1Cba involves: 129S2/SvPas	abnormal aorta elastic fiber morphology	J:32928
	abnormal diaphragm morphology	J:32928
	abnormal myocardial fiber morphology	J:32928
	abnormal myocardium layer morphology	J:32928
	abnormal skeletal muscle fiber morphology	J:137067
	abnormal vascular smooth muscle morphology	J:32928
	cardiac fibrosis	J:32928
	centrally nucleated skeletal muscle fibers	J:137067
	decreased skeletal muscle fiber number	J:137067
	dystrophic cardiac calcinosis	J:32928
	hemorrhage	J:32928
	increased skeletal muscle fiber size	J:137067
	myocardium necrosis	J:32928
	skeletal muscle fiber atrophy	J:137067
	skeletal muscle fiber necrosis	J:137067
	thin diaphragm muscle	J:32928
Destm1Cba/Destm1Cba involves: 129S2/SvPas * C57BL/6J	abnormal myocardial fiber physiology	J:130557
	cardiac fibrosis	J:130557
	cardiomyopathy	J:130557
	decreased cardiac muscle contractility	J:130557
	decreased left ventricle developed pressure	J:130557
	dystrophic cardiac calcinosis	J:130557
	enlarged heart	J:130557
	increased heart left ventricle wall thickness	J:130557
	increased heart left ventricle weight	J:130557
	increased heart weight	J:130557
	increased left ventricle diastolic pressure	J:130557
Destm1Ltho/Destm1Ltho involves: 129S2/SvPas * C57BL/6J * CBA	abnormal epicardium morphology	J:127515
	abnormal heart morphology	J:127515
	abnormal heart right ventricle morphology	J:127515
	abnormal intercalated disk morphology	J:127515
	abnormal interventricular septum morphology	J:127515
	abnormal myocardial fiber morphology	J:127515
	abnormal ventricle papillary muscle morphology	J:127515
	cardiac fibrosis	J:127515
	decreased myocardial fiber number	J:127515
	dystrophic cardiac calcinosis	J:127515
	myocardial fiber degeneration	J:127515
Tg(Myh6-Des)520Rbns/0 involves: FVB/N	no abnormal phenotype detected	J:108730
Tg(Myh6-Des*)641Rbns/0 involves: FVB/N	abnormal cardiac muscle relaxation	J:108730
	abnormal heart echocardiography feature	J:108730
	abnormal myocardial fiber morphology	J:108730
	abnormal myocardial fiber physiology	J:108730
	abnormal Z line morphology	J:108730
	cardiac hypertrophy	J:108730
	decreased ventricle muscle contractility	J:108730
	increased left ventricle diastolic pressure	J:108730
	increased myocardial fiber size	J:108730