Pcyt1a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pcyt1a
phosphate cytidylyltransferase 1, choline, alpha isoform
MGI:88557

24 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pcyt1a^tm1.1Irt/Pcyt1a^tm1.1Irt involves: FVB/N	abnormal preimplantation embryo development	J:97657
	absent blastocoele	J:97657
	embryonic growth arrest	J:97657
	embryonic lethality before implantation, complete penetrance	J:97657
	failure of embryo implantation	J:97657
Pcyt1a^tm1Irt/Pcyt1a^tm1Irt Lyz2^tm1(cre)Ifo/Lyz2⁺ involves: 129 * C57BL/6J	abnormal immune cell physiology	J:65639
	abnormal macrophage physiology	J:65639
Pcyt1a^tm1Irt/Pcyt1a^tm1Irt Tg(SFTPC-rtTA)5Jaw/0 Tg(tetO-cre)1Jaw/Tg(tetO-cre)1Jaw involves: C57BL/6J * FVB/N	abnormal lung saccule morphology	J:118292
	abnormal lung vasculature morphology	J:118292
	abnormal pulmonary alveolar sac morphology	J:118292
	abnormal pulmonary alveolus wall morphology	J:118292
	abnormal surfactant composition	J:118292
	abnormal surfactant secretion	J:118292
	abnormal type II pneumocyte morphology	J:118292
	atelectasis	J:118292
	cyanosis	J:118292
	decreased alveolar lamellar body number	J:118292
	decreased type II pneumocyte number	J:118292
	increased triglyceride level	J:118292
	neonatal lethality, complete penetrance	J:118292
	neonatal lethality, incomplete penetrance	J:118292
	pulmonary hyaline membrane formation	J:118292
	pulmonary vascular congestion	J:118292
	respiratory distress	J:118292

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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