Col5a1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Col5a1
collagen, type V, alpha 1
MGI:88457

19 phenotypes from 3 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Col5a1^em1Brle/Col5a1⁺ C57BL/6-Col5a1^em1Brle	abnormal cutaneous collagen fibril morphology	J:326524
	abnormal dermal layer morphology	J:326524
	decreased skin tensile strength	J:326524
	thin dermal layer	J:326524
Col5a1^tm1Rjw/Col5a1⁺ either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)	abnormal cutaneous collagen fibril morphology	J:113133
Col5a1^tm1Rjw/Col5a1⁺ involves: 129S6/SvEvTac * C57BL/6	abnormal aorta morphology	J:112728
	abnormal cutaneous collagen fibril morphology	J:112728
	abnormal dermal layer morphology	J:112728
	abnormal skin condition	J:112728
	abnormal skin morphology	J:112728
	decreased skin tensile strength	J:112728
Col5a1^tm1Rjw/Col5a1^tm1Rjw either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)	abnormal blood vessel morphology	J:113133
	abnormal cutaneous collagen fibril morphology	J:113133
	abnormal visceral yolk sac morphology	J:113133
	embryonic lethality during organogenesis, complete penetrance	J:113133
Col5a1^tm2.1Rjw/Col5a1^tm2.1Rjw involves: 129 * C57BL/6 * SJL	no abnormal phenotype detected	J:221469
Col5a1^tm2.1Rjw/Col5a1^tm2.1Rjw Tg(Kera-cre)KC4.3Wwk/0 involves: 129 * C57BL/6 * FVB/N * SJL	abnormal cornea anterior stroma morphology	J:221469
	abnormal cornea posterior stroma morphology	J:221469
	abnormal cornea stroma collagen fibril morphology	J:221469
	abnormal cornea stroma morphology	J:221469
	cornea opacity	J:221469
	decreased cornea stroma thickness	J:221469
	normal growth/size/body region phenotype	J:221469
	increased corneal light-scattering	J:221469

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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