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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cftr
cystic fibrosis transmembrane conductance regulator
MGI:88388
118 phenotypes from 17 alleles in 28 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cftrem3Cwr/Cftrem3Cwr
C57BL/6J-Cftrem3Cwr/Cwr 		decreased body length J:262928
decreased body weight J:262928
decreased survivor rate J:262928
intestinal obstruction J:262928
premature death J:262928
Cftrtm1.1Cwr/Cftrtm1.1Cwr
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 		abnormal intestinal goblet cell morphology J:142723
decreased intestinal epithelial chloride transmembrane transport J:142723
decreased respiratory epithelial chloride transmembrane transport J:142723
intestinal mucus accumulation J:142723
intestinal obstruction J:142723
postnatal growth retardation J:142723
postnatal lethality, incomplete penetrance J:142723
premature death J:142723
Cftrtm1.1Sdw/Cftrtm1.1Sdw
involves: C57BL/6 * C57BL/6J 		abnormal intestinal goblet cell morphology J:323560
decreased physiological sensitivity to xenobiotic J:323560
dilated crypt of Lieberkuhn J:323560
disheveled coat J:323560
intestinal obstruction J:323560
postnatal lethality, incomplete penetrance J:323560
premature death J:323560
normal respiratory system phenotype J:323560
Cftrtm1Cam/Cftrtm1Cam
involves: 129S/SvEv 		abnormal colon morphology J:23850
abnormal crypts of Lieberkuhn morphology J:23850
abnormal intestine morphology J:23850
abnormal lacrimal gland morphology J:23850
abnormal small intestine morphology J:23850
decreased body weight J:23850
decreased respiratory epithelial chloride transmembrane transport J:23850
decreased respiratory epithelial sodium ion transmembrane transport J:23850
dilated crypt of Lieberkuhn J:23850
dilated pancreatic duct J:23850
increased susceptibility to infection J:23850
intestinal mucus accumulation J:23850
intestinal obstruction J:2584, J:23850
meconium ileus J:2584, J:23850
peritoneal inflammation J:23850
postnatal lethality, incomplete penetrance J:2584, J:23850
premature death J:2584, J:23850
normal respiratory system phenotype J:23850
small cecum J:2584
Cftrtm1Cwr/Cftrtm1Cwr
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		no abnormal phenotype detected J:142723
Cftrtm1Eur/Cftrtm1Eur
B6.129P2-Cftrtm1Eur 		abnormal intestinal goblet cell morphology J:189205
abnormal small intestinal crypt cell physiology J:189205
abnormal small intestine crypts of Lieberkuhn morphology J:189205
Cftrtm1Eur/Cftrtm1Eur
involves: 129P2/OlaHsd * FVB/N 		abnormal gallbladder physiology J:28979
abnormal intestinal goblet cell morphology J:28979
abnormal large intestine crypts of Lieberkuhn morphology J:28979
decreased body weight J:28979
decreased intestinal epithelial chloride transmembrane transport J:28979
decreased respiratory epithelial chloride transmembrane transport J:28979
postnatal growth retardation J:28979
Cftrtm1Hgu/Cftrtm1Hgu
CF/1Ztm 		abnormal ileal goblet cell morphology J:112752
intestinal obstruction J:112752
lethality, incomplete penetrance J:112752
normal reproductive system phenotype J:112752
Cftrtm1Hgu/Cftrtm1Hgu
CF/3Ztm 		abnormal ileal goblet cell morphology J:112752
intestinal obstruction J:112752
lethality, incomplete penetrance J:112752
normal reproductive system phenotype J:112752
Cftrtm1Hgu/Cftrtm1Hgu
involves: 129P2/OlaHsd 		abnormal lung morphology J:24119
increased respiratory mucosa goblet cell number J:24119
increased susceptibility to bacterial infection J:24119
lung inflammation J:24119
normal respiratory system phenotype J:103284
Cftrtm1Hgu/Cftrtm1Hgu
involves: 129P2/OlaHsd * MF1 		abnormal colon morphology J:14614
abnormal vas deferens morphology J:14614
atelectasis J:14614
decreased intestinal epithelial chloride transmembrane transport J:14614
decreased respiratory epithelial chloride transmembrane transport J:14614
meconium ileus J:20037
postnatal lethality, incomplete penetrance J:20037
Cftrtm1Hsc/Cftrtm1Hsc
involves: 129S1/Sv * 129X1/SvJ 		postnatal lethality, complete penetrance J:31759
Cftrtm1Hsc/Cftrtm1Hsc
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ 		abnormal intestine physiology J:102288
postnatal lethality, incomplete penetrance J:31759
Cftrtm1Hsc/Cftrtm1Hsc
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J * DBA/2J 		abnormal intestine physiology J:102288
postnatal lethality, incomplete penetrance J:102288
Cftrtm1Hsc/Cftrtm1Hsc
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		postnatal lethality, incomplete penetrance J:31759
Cftrtm1Hsc/Cftrtm1Hsc
involves: 129S1/Sv * 129X1/SvJ * CD-1 		abnormal colon goblet cell morphology J:31759
abnormal crypts of Lieberkuhn morphology J:31759
abnormal intestinal mucosa morphology J:31759
abnormal small intestinal crypt cell physiology J:31759
abnormal small intestine goblet cell morphology J:31759
decreased body size J:31759
increased respiratory epithelial sodium ion transmembrane transport J:31759
intestinal obstruction J:31759
meconium ileus J:31759
postnatal growth retardation J:31759
postnatal lethality, incomplete penetrance J:31759
weight loss J:31759
Cftrtm1Hsc/Cftrtm1Hsc
involves: 129S1/Sv * 129X1/SvJ * DBA/2J 		preweaning lethality, complete penetrance J:31759
Cftrtm1Kth/Cftrtm1Kth
B6.129S7-Cftrtm1Kth 		abnormal uterine cervix morphology J:145380
absent estrous cycle J:145380
decreased corpora lutea number J:145380
decreased litter size J:145380
decreased ovary weight J:145380
decreased ovulation rate J:145380
decreased respiratory epithelial chloride transmembrane transport J:112450
decreased uterus weight J:145380
delayed sexual maturation J:145380
normal homeostasis/metabolism phenotype J:145380
impaired fertilization J:145380
impaired sperm migration in female genital tract J:145380
increased susceptibility to bacterial infection induced morbidity/mortality J:112450
intestinal obstruction J:112450
lung inflammation J:112450
postnatal growth retardation J:112450, J:145380
prolonged estrous cycle J:145380
reduced female fertility J:145380
small ovary J:145380
small uterus J:145380
thin uterus J:145380
Cftrtm1Kth/Cftrtm1Kth
involves: 129S7/SvEvBrd * C57BL/6J 		abnormal digestive system physiology J:29074
abnormal fluid regulation J:29074
abnormal intestine morphology J:29074
abnormal ion homeostasis J:29074
abnormal jejunum morphology J:29074
abnormal pancreas physiology J:29074
decreased body size J:29074
decreased body weight J:29074
dilated Brunner's gland J:29074
intestinal obstruction J:29074
peritoneal inflammation J:29074
postnatal lethality, incomplete penetrance J:29074
Cftrtm1Unc/Cftr+
involves: 129P2/OlaHsd 		asthenozoospermia J:122297
decreased litter size J:122297
impaired fertilization J:122297
impaired sperm capacitation J:122297
reduced male fertility J:122297
Cftrtm1Unc/Cftr+
involves: BALB/cJ * C57BL/6J 		transmission ratio distortion J:125558
Cftrtm1Unc/Cftrtm1Unc
B6.129P2-Cftrtm1Unc 		abnormal bronchus morphology J:44904
abnormal intestine morphology J:44904
abnormal pulmonary alveolus morphology J:44904
decreased respiratory epithelial chloride transmembrane transport J:44904
increased lung compliance J:44904
lung inflammation J:44904
postnatal growth retardation J:44904
postnatal lethality, incomplete penetrance J:44904
pulmonary interstitial fibrosis J:44904
Cftrtm1Unc/Cftrtm1Unc
B6.129P2-Cftrtm1Unc/J 		abnormal phospholipid level J:58571
abnormal uterine cervix morphology J:145380
absent estrous cycle J:145380
decreased body weight J:145380
decreased corpora lutea number J:145380
decreased intestinal epithelial sodium ion transmembrane transport J:32766
decreased litter size J:145380
decreased ovary weight J:145380
decreased ovulation rate J:145380
decreased respiratory epithelial chloride transmembrane transport J:112450
decreased respiratory epithelial sodium ion transmembrane transport J:112450
decreased uterus weight J:145380
delayed sexual maturation J:145380
dilated pancreatic acinus J:58571
normal homeostasis/metabolism phenotype J:145380
ileum hypertrophy J:58571
impaired fertilization J:145380
impaired sperm migration in female genital tract J:145380
increased susceptibility to bacterial infection induced morbidity/mortality J:112450
intestinal obstruction J:112450
lung inflammation J:58571, J:112450
pancreatic acinar cell zymogen granule accumulation J:58571
postnatal growth retardation J:112450
postnatal lethality, incomplete penetrance J:32766
prolonged estrous cycle J:145380
reduced female fertility J:145380
small ovary J:145380
small uterus J:145380
thin uterus J:145380
Cftrtm1Unc/Cftrtm1Unc
involves: 129P2/OlaHsd 		abnormal Brunner's gland morphology J:2079
abnormal colon morphology J:2079
abnormal crypts of Lieberkuhn morphology J:2079
abnormal gait J:2079
abnormal gallbladder morphology J:2079
abnormal gland morphology J:2079
abnormal intestine morphology J:2079
abnormal nasal mucosa morphology J:2079
abnormal pancreas morphology J:2079
abnormal paranasal sinus morphology J:2079
abnormal submandibular gland morphology J:2079
abnormal thymus involution J:2079
abnormal trachea gland morphology J:2079
abnormal trachea morphology J:2079
coiled cecum J:2079
decreased body size J:2079
dilated gallbladder J:2079
distended abdomen J:2079
female infertility J:2079
increased respiratory mucosa goblet cell number J:2079
intestinal obstruction J:2079
peritoneal inflammation J:2079
postnatal lethality, incomplete penetrance J:2079
premature death J:2079
small pancreas J:2079
spleen hyperplasia J:2079
Cftrtm1Unc/Cftrtm1Unc
involves: 129P2/OlaHsd * C57BL/6 * FVB/N 		abnormal intestinal goblet cell morphology J:21934
coiled cecum J:21934
decreased intestinal epithelial chloride transmembrane transport J:21934
dilated crypt of Lieberkuhn J:21934
postnatal lethality, incomplete penetrance J:21934
Cftrtm1Unc/Cftrtm1Unc
involves: 129P2/OlaHsd * C57BL/6J 		abnormal vital capacity J:44904
decreased respiratory epithelial chloride transmembrane transport J:44904
postnatal growth retardation J:44904
postnatal lethality, incomplete penetrance J:44904
normal respiratory system phenotype J:44904
Cftrtm2Cam/Cftrtm2Cam
involves: 129S/SvEv 		abnormal intestine physiology J:27734
abnormal large intestine crypts of Lieberkuhn morphology J:27734
abnormal small intestine crypts of Lieberkuhn morphology J:27734
decreased respiratory epithelial chloride transmembrane transport J:27734
normal endocrine/exocrine gland phenotype J:27734
intestinal obstruction J:27734
meconium ileus J:27734
peritoneal inflammation J:27734
postnatal lethality, incomplete penetrance J:27734
premature death J:27734
normal respiratory system phenotype J:27734
Cftrtm2Hgu/Cftrtm2Hgu
involves: 129P2/OlaHsd * C57BL/6 		abnormal digestive system physiology J:74740
abnormal intestinal goblet cell morphology J:74740
abnormal respiratory system physiology J:74740
normal craniofacial phenotype J:74740
normal reproductive system phenotype J:74740
Cftrtm2Kth/Cftrtm2Kth
involves: 129S7/SvEvBrd * C57BL/6J 		no abnormal phenotype detected J:29074
Cftrtm2Mrc/Cftrtm2Mrc
B6.129S6-Cftrtm2Mrc 		abnormal alveolar macrophage morphology J:112450
decreased neutrophil cell number J:112450
decreased respiratory epithelial chloride transmembrane transport J:112450
normal digestive/alimentary phenotype J:112450
increased susceptibility to bacterial infection induced morbidity/mortality J:112450
lung inflammation J:112450
postnatal growth retardation J:112450
Cftrtm3Bay/Cftrtm3Bay
involves: 129S7/SvEvBrd 		abnormal crypts of Lieberkuhn morphology J:29656
abnormal digestive system physiology J:29656
abnormal pancreas morphology J:29656
decreased body size J:29656
female infertility J:29656
intestinal obstruction J:29656
normal liver/biliary system phenotype J:29656
premature death J:29656
normal respiratory system phenotype J:29656
Cftrtm3Hgu/Cftrtm3Hgu
involves: 129P2/OlaHsd 		abnormal bile duct morphology J:32766
abnormal hepatocyte morphology J:32766
abnormal intestinal mucosa morphology J:32766
abnormal salivary gland morphology J:32766
abnormal submucosal gland morphology J:32766
bile duct epithelium hyperplasia J:32766
decreased body size J:32766
decreased body weight J:32766
decreased intestinal epithelial sodium ion transmembrane transport J:32766
decreased respiratory epithelial chloride transmembrane transport J:32766
decreased respiratory epithelial sodium ion transmembrane transport J:32766
decreased small intestinal villus number J:32766
dilated crypt of Lieberkuhn J:32766
normal endocrine/exocrine gland phenotype J:32766
enlarged gallbladder J:32766
gallbladder inflammation J:32766
intestinal obstruction J:32766
peritoneal inflammation J:32766
postnatal lethality, incomplete penetrance J:32766
normal reproductive system phenotype J:32766
normal respiratory system phenotype J:32766
Cftrtm3Mrc/Cftrtm3Mrc
B6.129S6-Cftrtm3Mrc 		decreased respiratory epithelial chloride transmembrane transport J:112450
increased susceptibility to bacterial infection induced morbidity/mortality J:112450
intestinal obstruction J:112450
lung inflammation J:112450
postnatal growth retardation J:112450
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory