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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Btk
Bruton agammaglobulinemia tyrosine kinase
MGI:88216
46 phenotypes from 9 alleles in 15 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Btkm1Anu/Btkm1Anu
involves: BXSB/MpJ * C57BL/6JAnu * SB/Le
decreased B cell number J:104190
Btkm2Anu/Btkm2Anu
C57BL/6NCrlAnu-Btkm2Anu
increased IgM level J:104190
increased immature B cell number J:104190
Btktm1a(EUCOMM)Hmgu/Y
C57BL/6N-Btktm1a(EUCOMM)Hmgu/Ics
decreased body weight J:165965
increased CD4-positive, alpha-beta T cell number J:165965
Btktm1Gsv/Y
involves: 129P2/OlaHsd * C57BL/6
abnormal B cell differentiation J:35769
abnormal B cell physiology J:94768
abnormal humoral immune response J:120989
abnormal immune system physiology J:35769
absent B-1a cells J:35769
absent mature B cells J:35769
decreased B cell number J:35769
decreased IgG3 level J:35769
decreased IgM level J:35769
decreased immature B cell number J:35769
decreased immunoglobulin level J:120989
Btktm1Gsv/Btk+
involves: 129P2/OlaHsd * C57BL/6
absent B-1a cells J:35769
decreased B cell number J:35769
decreased mature B cell number J:35769
Btktm1Witt/Btktm1Wk
involves: 129S4/SvJae * 129X1/SvJ
normal immune system phenotype J:104167
Btktm1Wk/Btktm1Wk
involves: 129S4/SvJae * C57BL/6
abnormal B cell activation J:28968
abnormal B cell differentiation J:28968
abnormal lymph node germinal center morphology J:82298
decreased B cell proliferation J:82298
decreased IgG3 level J:28968, J:82298
decreased IgM level J:28968, J:82298
decreased mature B cell number J:28968, J:82298
decreased spleen germinal center number J:82298
decreased spleen germinal center size J:82298
increased pro-B cell number J:28968
Btktm1Wk/Btktm1Wk
Tg(IGH-Btk)1Witt/0
involves: 129S4/SvJae * 129X1/SvJ * BALB/c * C3H * C57BL/6
decreased B cell proliferation J:82430
Btkvila/Btkvila
C57BL/6JAnu-Btkvila/AnuApb
abnormal leukocyte morphology J:104190
decreased B cell number J:104190
decreased IgD level J:104190
increased IgE level J:104190
increased IgG level J:104190
Btkxid/Y
CBA/HN-Btkxid
decreased B cell number J:81429
decreased B cell proliferation J:81429
decreased splenocyte number J:81429
Btkxid/?
involves: BALB/c * CBA/N
decreased B cell proliferation J:108696
decreased B-1 B cell number J:108696
decreased IgG3 level J:108696
decreased IgM level J:108696
decreased mature B cell number J:108696
Btkxid/Y
involves: CBA/HN * DBA/2N
decreased B cell number J:81429
decreased B cell proliferation J:81429
spleen hypoplasia J:81429
Btkxid/Btkxid
B6.CBA-Btkxid
decreased transitional stage B cell number J:145687
Btkxid/Btkxid
CBA/CaHN-Btkxid/J
abnormal macrophage physiology J:92639
abnormal neutrophil physiology J:92639
decreased acute inflammation J:92639
decreased follicular B cell number J:69477
decreased neutrophil cell number J:92639
decreased susceptibility to experimental autoimmune encephalomyelitis J:92639
impaired myelopoiesis J:92639
impaired neutrophil phagocytosis J:92639
increased susceptibility to bacterial infection induced morbidity/mortality J:128518
increased susceptibility to induced colitis J:92639
Btkxid/Btkxid
CBA/HN-Btkxid
abnormal bone marrow cell number J:7981
abnormal lymphopoiesis J:7981
abnormal pre-B cell morphology J:7981
autoimmune response J:125114
decreased B cell number J:81429
decreased B cell proliferation J:81429
decreased splenocyte number J:81429
Btkxid/Btkxid
involves: C57BL/6 * CBA
normal immune system phenotype J:113083
Btkxid/Btkxid
involves: CBA/HN * DBA/2N
abnormal B cell physiology J:81429
abnormal B cell proliferation J:81429
decreased B cell number J:81429
spleen hypoplasia J:81429
Btkxid/?
Tg(IGH-Btk)1Witt/0
involves: BALB/c * C3H * C57BL/6 * CBA/N
decreased B cell proliferation J:108696
decreased B-1 B cell number J:108696
decreased IgG3 level J:108696
decreased IgM level J:108696
Btkxid/?
Tg(IGH-Btk)1Witt/Tg(IGH-Btk)1Witt
involves: BALB/c * C3H * C57BL/6 * CBA/N
decreased B cell proliferation J:108696
decreased B-1 B cell number J:108696
decreased IgG3 level J:108696
decreased IgM level J:108696

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory