Btk Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Btk
Bruton agammaglobulinemia tyrosine kinase
MGI:88216

47 phenotypes from 9 alleles in 15 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
\Btk^m1Anu/\Btk^m1Anu involves: BXSB/MpJ * C57BL/6JAnu * SB/Le	decreased B cell number	J:104190
\Btk^m2Anu/\Btk^m2Anu C57BL/6NCrlAnu-Btk^m2Anu	increased IgM level	J:104190
\Btk^m2Anu/\Btk^m2Anu C57BL/6NCrlAnu-Btk^m2Anu	increased immature B cell number	J:104190
\Btk^{tm1a(EUCOMM)Hmgu}/Y C57BL/6N-Btk^{tm1a(EUCOMM)Hmgu}/Ics	decreased body weight	J:165965
	increased CD4-positive, alpha-beta T cell number	J:165965
\Btk^tm1Gsv/Y involves: 129P2/OlaHsd * C57BL/6	abnormal B cell calcium ion homeostasis	J:94768
	abnormal B cell differentiation	J:35769
	abnormal humoral immune response	J:120989
	abnormal immune system physiology	J:35769
	absent B-1a cells	J:35769
	absent mature B cells	J:35769
	decreased B cell number	J:35769
	decreased IgG3 level	J:35769
	decreased IgM level	J:35769
	decreased immature B cell number	J:35769
	decreased immunoglobulin level	J:120989
\Btk^tm1Gsv/\Btk⁺ involves: 129P2/OlaHsd * C57BL/6	absent B-1a cells	J:35769
	decreased B cell number	J:35769
	decreased mature B cell number	J:35769
\Btk^tm1Witt/\Btk^tm1Wk involves: 129S4/SvJae * 129X1/SvJ	normal immune system phenotype	J:104167
\Btk^tm1Wk/\Btk^tm1Wk involves: 129S4/SvJae * C57BL/6	abnormal B cell activation	J:28968
	abnormal B cell differentiation	J:28968
	abnormal lymph node germinal center morphology	J:82298
	decreased B cell proliferation	J:82298
	decreased IgG3 level	J:28968, J:82298
	decreased IgM level	J:28968, J:82298
	decreased mature B cell number	J:28968, J:82298
	decreased spleen germinal center number	J:82298
	decreased spleen germinal center size	J:82298
	increased pro-B cell number	J:28968
\Btk^tm1Wk/\Btk^tm1Wk \Tg(IGH-Btk)1Witt/0 involves: 129S4/SvJae * 129X1/SvJ * BALB/c * C3H * C57BL/6	decreased B cell proliferation	J:82430
\Btk^vila/\Btk^vila C57BL/6JAnu-Btk^vila/AnuApb	abnormal leukocyte morphology	J:104190
	decreased B cell number	J:104190
	decreased IgD level	J:104190
	increased IgE level	J:104190
	increased IgG level	J:104190
\Btk^xid/Y CBA/HN-Btk^xid	decreased B cell number	J:81429
	decreased B cell proliferation	J:81429
	decreased splenocyte number	J:81429
\Btk^xid/? involves: BALB/c * CBA/N	decreased B cell proliferation	J:108696
	decreased B-1 B cell number	J:108696
	decreased IgG3 level	J:108696
	decreased IgM level	J:108696
	decreased mature B cell number	J:108696
\Btk^xid/Y involves: CBA/HN * DBA/2N	decreased B cell number	J:81429
	decreased B cell proliferation	J:81429
	spleen hypoplasia	J:81429
\Btk^xid/\Btk^xid B6.CBA-Btk^xid	decreased transitional stage B cell number	J:145687
\Btk^xid/\Btk^xid CBA/CaHN-Btk^xid/J	abnormal macrophage physiology	J:92639
	abnormal neutrophil physiology	J:92639
	decreased acute inflammation	J:92639
	decreased follicular B cell number	J:69477
	decreased neutrophil cell number	J:92639
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:92639
	impaired myelopoiesis	J:92639
	impaired neutrophil phagocytosis	J:92639
	increased susceptibility to bacterial infection induced morbidity/mortality	J:128518
	increased susceptibility to induced colitis	J:92639
\Btk^xid/\Btk^xid CBA/HN-Btk^xid	abnormal bone marrow cell number	J:7981
	abnormal lymphopoiesis	J:7981
	abnormal pre-B cell morphology	J:7981
	autoimmune response	J:125114
	decreased B cell number	J:81429
	decreased B cell proliferation	J:81429
	decreased splenocyte number	J:81429
\Btk^xid/\Btk^xid involves: C57BL/6 * CBA	normal immune system phenotype	J:113083
\Btk^xid/\Btk^xid involves: CBA/HN * DBA/2N	abnormal B cell physiology	J:81429
	abnormal B cell proliferation	J:81429
	decreased B cell number	J:81429
	spleen hypoplasia	J:81429
\Btk^xid/? \Tg(IGH-Btk)1Witt/0 involves: BALB/c * C3H * C57BL/6 * CBA/N	decreased B cell proliferation	J:108696
	decreased B-1 B cell number	J:108696
	decreased IgG3 level	J:108696
	decreased IgM level	J:108696
\Btk^xid/? \Tg(IGH-Btk)1Witt/\Tg(IGH-Btk)1Witt involves: BALB/c * C3H * C57BL/6 * CBA/N	decreased B cell proliferation	J:108696
	decreased B-1 B cell number	J:108696
	decreased IgG3 level	J:108696
	decreased IgM level	J:108696

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24