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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Rr253
regulatory region 253
MGI:7331605
25 phenotypes from 5 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Rr253em1Kmm/Rr253em1Kmm
C57BL/6-Rr253em1Kmm 		abnormal class switch recombination J:316113
abnormal effector T cell number J:316113
abnormal peritoneal macrophage morphology J:316113
abnormal spleen B cell follicle morphology J:316113
decreased B cell number J:316113
decreased mature NK cell number J:316113
decreased monocyte cell number J:316113
decreased plasmacytoid dendritic cell number J:316113
decreased spleen B cell follicle number J:316113
decreased spleen B cell follicle size J:316113
normal embryo phenotype J:316113
normal hematopoietic system phenotype J:316113
increased dendritic cell number J:316113
increased lymphocyte cell number J:316113
increased neutrophil cell number J:316113
increased NK cell number J:316113
increased susceptibility to viral infection induced morbidity/mortality J:316113
increased T cell number J:316113
spleen hypoplasia J:316113
Rr253em3Kmm/Rr253em3Kmm
C57BL/6J-Rr253em3Kmm 		decreased dendritic cell number J:334296
Rr253em4Kmm/Rr253em4Kmm
C57BL/6J-Rr253em4Kmm 		normal hematopoietic system phenotype J:334296
normal immune system phenotype J:334296
Rr253em5Kmm/Rr253em5Kmm
C57BL/6J-Rr253em5Kmm 		decreased dendritic cell number J:334296
increased dendritic cell number J:334296
Rr253em6Kmm/Rr253em6Kmm
C57BL/6J-Rr253em6Kmm 		abnormal common myeloid progenitor cell morphology J:334296
abnormal T-helper 2 physiology J:334296
decreased dendritic cell number J:334296
decreased granulocyte monocyte progenitor cell number J:334296
decreased monocyte cell number J:334296
decreased plasmacytoid dendritic cell number J:334296
normal hematopoietic system phenotype J:334296
normal immune system phenotype J:334296
increased dendritic cell number J:334296
increased susceptibility to parasitic infection induced morbidity/mortality J:334296
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory