Mcph1 Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mcph1
microcephaly, primary autosomal recessive 1
MGI:2443308

7 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
B2m^tm1Unc/B2m^tm1Unc Emv30^b/Emv30^b Prkdc^scid/Prkdc^scid Tg(B2M)55Hpl/? Mcph1^{Tg(HLA-A2.1)1Enge}/? NOD.Cg-B2m^tm1Unc Mcph1^{Tg(HLA-A2.1)1Enge} Emv30^b Prkdc^scid Tg(B2M)55Hpl/Dvs	decreased susceptibility to autoimmune diabetes	J:109851
B2m^tm1Unc/B2m^tm1Unc Tg(B2M)55Hpl/Tg(B2M)55Hpl Mcph1^{Tg(HLA-A2.1)1Enge}/Mcph1^{Tg(HLA-A2.1)1Enge} NOD.Cg-B2m^tm1Unc Mcph1^{Tg(HLA-A2.1)1Enge} Tg(B2M)55Hpl	increased susceptibility to autoimmune diabetes	J:109851
Mcph1^{Tg(HLA-A2.1)1Enge}/Mcph1⁺ involves: C57BL/6	abnormal immune tolerance	J:52612
Mcph1^{Tg(HLA-A2.1)1Enge}/Mcph1⁺ NOD.B6-Mcph1^{Tg(HLA-A2.1)1Enge}	increased susceptibility to autoimmune diabetes	J:109851
Mcph1^{Tg(HLA-A2.1)1Enge}/Mcph1^{Tg(HLA-A2.1)1Enge} NOD.B6-Mcph1^{Tg(HLA-A2.1)1Enge}	normal immune system phenotype	J:109851
	increased susceptibility to autoimmune diabetes	J:109851
Prkdc^scid/Prkdc^scid Mcph1^{Tg(HLA-A2.1)1Enge}/Mcph1⁺ NOD.Cg-Mcph1^{Tg(HLA-A2.1)1Enge} Prkdc^scid/Dvs	abnormal splenocyte morphology	J:91764
Prkdc^scid/Prkdc^scid Tg(B2M)55Hpl/0 Mcph1^{Tg(HLA-A2.1)1Enge}/Mcph1⁺ NOD.Cg-Mcph1^{Tg(HLA-A2.1)1Enge} Prkdc^scid Tg(B2M)55Hpl/Sz	abnormal response to transplant	J:91764
	increased circulating glucose level	J:91764

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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