Orai2 Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Orai2
ORAI calcium release-activated calcium modulator 2
MGI:2443195

10 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Orai1^tm1.1Hjm/Orai1^tm1.1Hjm Orai2^{tm1.1(KOMP)Vlcg}/Orai2^{tm1.1(KOMP)Vlcg} Tg(Cd4-cre)1Cwi/0 B6.Cg-Tg(Cd4-cre)1Cwi Orai1^tm1.1Hjm Orai2^{tm1.1(KOMP)Vlcg}	abnormal CD4-positive helper T cell morphology	J:241365
	abnormal T cell physiology	J:241365
	decreased germinal center B cell number	J:241365
	decreased IgG level	J:241365
	decreased regulatory T cell number	J:241365
	decreased single-positive T cell number	J:241365
	normal hematopoietic system phenotype	J:241365
	normal immune system phenotype	J:241365
	lymph node hyperplasia	J:241365
	spleen hyperplasia	J:241365

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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