Brip1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Brip1
BRCA1 interacting protein C-terminal helicase 1
MGI:2442836

42 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Brip1^em1(IMPC)J/Brip1^em1(IMPC)J C57BL/6NJ-Brip1^em1(IMPC)J/Mmjax	cataract	J:211773
	decreased grip strength	J:211773
	hyperactivity	J:211773
	increased mean corpuscular volume	J:211773
	thrombocytopenia	J:211773
Brip1^{Gt(RRI409)Byg}/Brip1^{Gt(RRI409)Byg} involves: 129P2/OlaHsd	abnormal cell physiology	J:227115, J:227337
	abnormal chiasmata formation	J:227337
	abnormal chromosome morphology	J:227115
	abnormal DNA replication	J:227115
	abnormal double-strand DNA break repair	J:227115, J:227337
	abnormal ovary development	J:227115
	abnormal seminiferous tubule epithelium morphology	J:227337
	abnormal seminiferous tubule morphology	J:227115
	abnormal spermatogonia morphology	J:227115
	abnormal spermatogonia proliferation	J:227337
	abnormal X-Y chromosome synapsis during male meiosis	J:227337
	chromosomal instability	J:227115
	decreased cell proliferation	J:227337
	decreased litter size	J:227115
	decreased primary ovarian follicle number	J:227115
	decreased primordial germ cell number	J:227337
	decreased primordial germ cell proliferation	J:227337
	decreased testis weight	J:227115, J:227337
	early cellular replicative senescence	J:227115
	endometrium hyperplasia	J:227115
	hepatic steatosis	J:227115
	increased adenocarcinoma incidence	J:227115
	increased adenoma incidence	J:227115
	increased cellular sensitivity to DNA damaging agents	J:227115
	increased Harderian gland adenoma incidence	J:227115
	increased lymphoma incidence	J:227115
	increased pituitary adenoma incidence	J:227115
	increased primordial germ cell apoptosis	J:227337
	increased Sertoli cell number	J:227115
	increased tumor incidence	J:227115
	induced chromosome breakage	J:227115
	oligozoospermia	J:227337
	ovary cyst	J:227115
	reduced fertility	J:227115
	small testis	J:227115, J:227337
	testicular atrophy	J:227115
	testis hypoplasia	J:227337

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23