Brip1^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Brip1^em1(IMPC)J
• Name: BRCA1 interacting protein C-terminal helicase 1; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:5823287
• Synonyms: Brip1^em1J
• Gene: Brip1 Location: Chr11:85948964-86092019 bp, - strand Genetic Position: Chr11, 51.61 cM
• Alliance: Brip1^em1(IMPC)J page
• IMPC: Brip1 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele from project Brip1-8371J-M2241 was generated at The Jackson Laboratory by injecting Cas9 RNA and 4 guide sequences GCTCAGTAAAAACACACACG, TGATATTTCAGACTGCTAGT, CAGGAAACACAGTTACAGCG and CTTCTGTGCTGTTCTAGTCG, which resulted in a 407 bp deletion beginning at Chromosome 11 negative strand position 86,198,119 bp, CGCGCTGTAACTGTGTTTCC, and ending after CGTGTGTGTTTTTACTGAGC at 86,197,713 bp (GRCm38/mm10). This mutation deletes exon 3 and 295 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 31 and early truncation 7 amino acids later. (J:188991)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Brip1 Mutation: 63 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 3 reference(s)