Sirt7 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sirt7
sirtuin 7
MGI:2385849

33 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sirt7^tm1Evbo/Sirt7^tm1Evbo involves: 129/Sv * C57BL/6	abnormal cytokine level	J:147652
	abnormal response to injury	J:147652
	cardiac fibrosis	J:147652
	cardiac hypertrophy	J:147652
	cardiomyopathy	J:147652
	decreased subcutaneous adipose tissue amount	J:147652
	increased cardiomyocyte apoptosis	J:147652
	increased cellular sensitivity to hydrogen peroxide	J:147652
	increased granulocyte number	J:147652
	increased heart weight	J:147652
	increased interleukin-4 secretion	J:147652
	increased interleukin-12 secretion	J:147652
	increased interleukin-13 secretion	J:147652
	increased myocardial fiber size	J:147652
	increased sensitivity to induced cell death	J:147652
	kyphosis	J:147652
	lipofuscinosis	J:147652
	premature aging	J:147652
	premature death	J:147652
Sirt7^tm1Fwa/Sirt7^tm1Fwa involves: 129S1/Sv	abnormal hepatocyte morphology	J:205529
	abnormal lipid homeostasis	J:205529
	abnormal liver physiology	J:205529
	decreased body weight	J:205529
	decreased circulating triglyceride level	J:205529
	decreased circulating VLDL triglyceride level	J:205529
	decreased epididymal fat pad weight	J:205529
	enlarged liver	J:205529
	hepatic steatosis	J:205529
	increased food intake	J:205529
	increased liver triglyceride level	J:205529
	increased macrophage cell number	J:205529
	liver inflammation	J:205529
	pale liver	J:205529

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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