Arhgef18 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Arhgef18
Rho/Rac guanine nucleotide exchange factor 18
MGI:2142567

19 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Arhgef18^em2Cya/Arhgef18⁺ Nkx2-5^em1(cre)Smoc/Nkx2-5⁺ involves: C57BL/6JCya * C57BL/6JSmoc	abnormal cell cytoskeleton morphology	J:379569
	abnormal myocardial fiber morphology	J:379569
	abnormal myocardium layer morphology	J:379569
	normal cardiovascular system phenotype	J:379569
	normal growth/size/body region phenotype	J:379569
	normal mortality/aging	J:379569
Arhgef18^em2Cya/Arhgef18^em2Cya Nkx2-5^em1(cre)Smoc/Nkx2-5⁺ involves: C57BL/6JCya * C57BL/6JSmoc	abnormal cell cytoskeleton morphology	J:379569
	abnormal myocardial fiber morphology	J:379569
	abnormal myocardium layer morphology	J:379569
	decreased body weight	J:379569
	decreased heart left ventricle anterior wall thickness	J:379569
	decreased heart left ventricle muscle contractility	J:379569
	dilated cardiomyopathy	J:379569
	dilated heart left ventricle	J:379569
	increased heart left ventricle size	J:379569
	increased heart right ventricle size	J:379569
	increased heart ventricle size	J:379569
	normal mortality/aging	J:379569
	slow postnatal weight gain	J:379569
Arhgef18^{Gt(OSTGST002860)Lex}/Arhgef18^{Gt(OSTGST002860)Lex} B6;129S5-Arhgef18^{Gt(OSTGST002860)Lex}/Ieg	preweaning lethality, incomplete penetrance	J:82809
Arhgef18^{tm1b(KOMP)Mbp}/Arhgef18⁺ C57BL/6N-Arhgef18^{tm1b(KOMP)Mbp}/H	abnormal retina morphology	J:211773
	increased circulating amylase level	J:211773
Arhgef18^{tm1b(KOMP)Mbp}/Arhgef18^{tm1b(KOMP)Mbp} C57BL/6N-Arhgef18^{tm1b(KOMP)Mbp}/H	preweaning lethality, complete penetrance	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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