Arl4d Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Arl4d
ADP-ribosylation factor-like 4D
MGI:1933155

20 phenotypes from 2 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Arl4d^{tm1a(EUCOMM)Wtsi}/Arl4d^{tm1a(EUCOMM)Wtsi} B6JTyr;B6N-Arl4d^{tm1a(EUCOMM)Wtsi}/Wtsi	abnormal rib morphology	J:175295
	decreased body length	J:175295
	decreased body weight	J:175295
	decreased bone mineral content	J:175295
	decreased bone mineral density	J:175295
	decreased lean body mass	J:175295
	decreased lumbar vertebrae number	J:175295
	decreased rib number	J:175295
	decreased thoracic vertebrae number	J:175295
	increased sacral vertebrae number	J:175295
Arl4d^{tm1a(EUCOMM)Wtsi}/Arl4d^{tm1a(EUCOMM)Wtsi} involves: C57BL/6N	abnormal CD4-positive T cell differentiation	J:330548
	abnormal CD8-positive, alpha-beta T cell physiology	J:267938
	abnormal T cell physiology	J:330548
	decreased susceptibility to induced colitis	J:330548
	normal immune system phenotype	J:267938
	increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number	J:330548
	increased interferon-gamma secretion	J:267938
	increased interleukin-2 secretion	J:267938, J:330548
	increased KLRG1+ CD8 alpha-beta T cell number	J:267938
	increased regulatory T cell number	J:330548
Arl4d^{tm1c(EUCOMM)Wtsi}/Arl4d^{tm1c(EUCOMM)Wtsi} Foxp3^{tm4(YFP/icre)Ayr}/Y involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	abnormal T cell physiology	J:330548
	normal immune system phenotype	J:330548
Arl4d^{tm1c(EUCOMM)Wtsi}/Arl4d^{tm1c(EUCOMM)Wtsi} Tg(Cd4-cre)1Cwi/0 involves: C57BL/6 * C57BL/6N * DBA/2	abnormal CD4-positive T cell differentiation	J:330548
	abnormal T cell physiology	J:330548
	increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number	J:330548
	increased interleukin-2 secretion	J:330548

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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