Ltn1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ltn1
listerin E3 ubiquitin protein ligase 1
MGI:1926163

34 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ltn1^{Gt(RRR322)Byg}/Ltn1^{Gt(RRR322)Byg} involves: 129P2/OlaHsd	embryonic lethality	J:146493
Ltn1^{Gt(RRR322)Byg}/Ltn1^lister involves: 129P2/OlaHsd * C57BL/6	abnormal motor capabilities/coordination/movement	J:146493
	limb grasping	J:146493
Ltn1^lister/Ltn1^lister C57BL/6-Ltn1^lister	abnormal motor coordination/balance	J:146493
	abnormal muscle regeneration	J:146493
	abnormal neurite morphology	J:146493
	abnormal neuron morphology	J:146493
	abnormal neuron physiology	J:146493
	abnormal physical strength	J:146493
	astrocytosis	J:146493
	bradykinesia	J:146493
	decreased body size	J:146493
	decreased body weight	J:146493
	decreased grip strength	J:146493
	decreased skeletal muscle fiber size	J:146493
	impaired balance	J:146493
	impaired righting response	J:146493
	limb grasping	J:146493
	motor neuron degeneration	J:146493
	muscular atrophy	J:146493
	neuron degeneration	J:146493
	paralysis	J:146493
	paraparesis	J:146493
	slow postnatal weight gain	J:146493
	weaving	J:146493
Ltn1^{tm1b(EUCOMM)Hmgu}/Ltn1^{tm1b(EUCOMM)Hmgu} C57BL/6N-Ltn1^{tm1b(EUCOMM)Hmgu}/Ccpcz	abnormal cornea morphology	J:211773
	decreased body weight	J:211773
	decreased circulating alkaline phosphatase level	J:211773
	increased airway resistance	J:211773
	increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number	J:211773
	increased lung elastance	J:211773
	increased lung tissue damping	J:211773
	increased red blood cell distribution width	J:211773
	no spontaneous movement	J:211773
	preweaning lethality, incomplete penetrance	J:211773
	thrombocytopenia	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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