Nckap1l Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nckap1l
NCK associated protein 1 like
MGI:1926063

57 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nckap1l^m1Btlr/Nckap1l^m1Btlr C57BL/6J-Nckap1l^m1Btlr	decreased alpha-beta T cell number	J:272079
	decreased B cell number	J:272079
	decreased body weight	J:272079
	decreased CD4-positive, alpha-beta T cell number	J:272079
	decreased CD8-positive, alpha-beta T cell number	J:272079
	decreased CD8-positive, naive alpha-beta T cell number	J:272079
	decreased central memory CD8 positive, alpha-beta T cell number	J:272079
	decreased NK cell number	J:272079
	increased alpha-beta T cell number	J:272079
	increased CD8-positive, alpha-beta T cell number	J:272079
	increased effector memory CD4-positive, alpha-beta T cell number	J:272079
	increased effector memory CD8-positive, alpha-beta T cell number	J:272079
Nckap1l^m1Iri/Nckap1l^m1Iri involves: C57BL/6	abnormal CD4-positive T cell differentiation	J:141377
	abnormal common myeloid progenitor cell morphology	J:141377
	abnormal epididymis morphology	J:141377
	abnormal erythroid progenitor cell morphology	J:141377
	abnormal immune system organ morphology	J:141377
	abnormal liver morphology	J:141377
	abnormal lymphopoiesis	J:141377
	abnormal regulatory T cell number	J:141377
	abnormal renal glomerulus morphology	J:141377
	abnormal thoracic cavity morphology	J:141377
	abnormal thymus lobule morphology	J:141377
	acanthocytosis	J:141377
	amyloidosis	J:141377
	cardiac fibrosis	J:141377
	dacryocytosis	J:141377
	decreased CD4-positive, alpha-beta T cell number	J:141377
	decreased CD8-positive, alpha-beta T cell number	J:141377
	decreased double-positive T cell number	J:141377
	decreased hematocrit	J:141377
	decreased lymphocyte cell number	J:141377
	decreased mature B cell number	J:141377
	decreased mature gamma-delta T cell number	J:141377
	decreased mean corpuscular volume	J:141377
	decreased T cell proliferation	J:141377
	extramedullary hematopoiesis	J:141377
	heart inflammation	J:141377
	hypochromic microcytic anemia	J:141377
	impaired macrophage phagocytosis	J:141377
	impaired neutrophil chemotaxis	J:141377
	impaired neutrophil phagocytosis	J:141377
	increased circulating interleukin-6 level	J:141377
	increased circulating interleukin-17 level	J:141377
	increased double-negative T cell number	J:141377
	increased erythrocyte osmotic fragility	J:141377
	increased interleukin-6 secretion	J:141377
	increased interleukin-17 secretion	J:141377
	increased leukocyte cell number	J:141377
	increased neutrophil cell number	J:141377
	increased tumor necrosis factor secretion	J:141377
	liver inflammation	J:141377
	lung inflammation	J:141377
	lymph node hypoplasia	J:141377
	poikilocytosis	J:141377
	reticulocytosis	J:141377
	schistocytosis	J:141377
	spleen hyperplasia	J:141377
	thymus hypoplasia	J:141377

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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