Arfgap2 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Arfgap2
ARF GTPase activating protein 2
MGI:1924288

7 phenotypes from 1 allele in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Arfgap2^{tm1c(EUCOMM)Hmgu}/Arfgap2^{tm1c(EUCOMM)Hmgu} Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ involves: 129S4/SvJae * C57BL/6J * C57BL/6N * C57BL/10 * CBA/Ca	normal immune system phenotype	J:363611
Arfgap2^{tm1c(EUCOMM)Hmgu}/Arfgap2^{tm1c(EUCOMM)Hmgu} Lyz2^tm1(cre)Ifo/Lyz2⁺ involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J * C57BL/6N	normal immune system phenotype	J:363611
Arfgap2^{tm1c(EUCOMM)Hmgu}/Arfgap2^{tm1c(EUCOMM)Hmgu} Tg(CAG-cre/Esr1)5Amc/0 involves: 129S4/SvJae C57BL/6J * C57BL/6N	abnormal macrophage activation involved in immune response	J:363611
	decreased interferon-beta secretion	J:363611
	decreased interleukin-6 secretion	J:363611
	decreased level of surface class I molecules	J:363611
	decreased level of surface class II molecules	J:363611
	decreased macrophage cytokine production	J:363611
	normal immune system phenotype	J:363611
Arfgap2^{tm1c(EUCOMM)Hmgu}/Arfgap2^{tm1c(EUCOMM)Hmgu} Tg(Cd4-cre)1Cwi/0 involves: 129S4/SvJae * C57BL/6J * C57BL/6N	normal immune system phenotype	J:363611

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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