Dis3 Phenotype Annotations

About Help FAQ

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dis3
DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
MGI:1919912

16 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dis3^tm1.1Adki/Dis3⁺ C57BL/6N-Dis3^tm1.1Adki	ascites	J:385017
	normal cellular phenotype	J:385017
	chromosome breakage	J:385017
	decreased body size	J:385017
	normal growth/size/body region phenotype	J:385017
	normal hematopoietic system phenotype	J:385017
	increased plasmacytoma incidence	J:385017
Dis3^tm1.1Adki/Dis3⁺ CAnN.B6-Dis3^tm1.1Adki	chromosome breakage	J:385017
Dis3^tm1.1Adki/Dis3^tm1.1Adki C57BL/6N-Dis3^tm1.1Adki	prenatal lethality, complete penetrance	J:385017
Dis3^tm1.1Uba/Dis3^tm1.1Uba Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺ involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac	abnormal B cell morphology	J:302856
	abnormal class switch recombination	J:302856
Dis3^{tm1e.1(EUCOMM)Hmgu}/Dis3⁺ C57BL/6N-Dis3^{tm1e.1(EUCOMM)Hmgu}/Ieg	abnormal retina blood vessel morphology	J:211773
	abnormal retina morphology	J:211773
	abnormal vitreous body morphology	J:211773
	impaired glucose tolerance	J:211773
	increased startle reflex	J:211773
Dis3^{tm1e.1(EUCOMM)Hmgu}/Dis3^{tm1e.1(EUCOMM)Hmgu} C57BL/6N-Dis3^{tm1e.1(EUCOMM)Hmgu}/Ieg	preweaning lethality, complete penetrance	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 06/16/2026 MGI 6.24