Dis3 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dis3
DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
MGI:1919912

9 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dis3^tm1.1Uba/Dis3^tm1.1Uba Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺ involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac	abnormal B cell morphology	J:302856
	abnormal class switch recombination	J:302856
Dis3^{tm1e.1(EUCOMM)Hmgu}/Dis3⁺ C57BL/6N-Dis3^{tm1e.1(EUCOMM)Hmgu}/Ieg	abnormal optic disk morphology	J:211773
	abnormal retina blood vessel morphology	J:211773
	abnormal retina morphology	J:211773
	abnormal vitreous body morphology	J:211773
	impaired glucose tolerance	J:211773
	increased startle reflex	J:211773
Dis3^{tm1e.1(EUCOMM)Hmgu}/Dis3^{tm1e.1(EUCOMM)Hmgu} C57BL/6N-Dis3^{tm1e.1(EUCOMM)Hmgu}/Ieg	preweaning lethality, complete penetrance	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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