Dis3^tm1.1Adki
Targeted Allele Detail

Summary

• Symbol: Dis3^tm1.1Adki
• Name: DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease; targeted mutation 1.1, Andrzej Dziembowski
• MGI ID: MGI:8353672
• Synonyms: Dis3^G766R
• Gene: Dis3 Location: Chr14:99314070-99337217 bp, - strand Genetic Position: Chr14, 49.25 cM, cytoband E2.1
• Alliance: Dis3^tm1.1Adki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:385017
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Single point mutation
• Mutation details: Glycine codon 766 (GGC) in exon 17 was changed to arginine (CGC) (c.2296G>C, p.G766R) and a loxP site flanked neomycin resistance gene and CAG-cre/ERT2 cassette was inserted into intron 19. The neo cassette was removed through subsequent tamoxifen-induced Cre-mediated recombination. The mutation is the equivalent of the same human mutation associated with oncogenic chromosomal translocations in B cells that lead to multiple myeloma (MM). (J:385017)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dis3 Mutation: 41 strains or lines available

References

• Original: J:385017 Kulinski TM, et al., DIS3 mutations enhance AID-driven translocations during B-cell activation, promoting transformation to multiple myeloma. Nat Commun. 2026 Mar 14;17(1)
• All: 1 reference(s)