Phenotypes associated with this allele

• Allele Symbol: Dis3^tm1.1Adki
• Allele Name: targeted mutation 1.1, Andrzej Dziembowski
• Allele ID: MGI:8353672
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dis3^tm1.1Adki/Dis3^tm1.1Adki	C57BL/6N-Dis3^tm1.1Adki	MGI:8353847
ht2	Dis3^tm1.1Adki/Dis3^+	CAnN.B6-Dis3^tm1.1Adki	MGI:8353854
ht3	Dis3^tm1.1Adki/Dis3^+	C57BL/6N-Dis3^tm1.1Adki	MGI:8353848

Genotype
MGI:8353847

hm1

• Allelic Composition: Dis3^tm1.1Adki/Dis3^tm1.1Adki
• Genetic Background: C57BL/6N-Dis3^tm1.1Adki

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:385017 )

Genotype
MGI:8353854

ht2

• Allelic Composition: Dis3^tm1.1Adki/Dis3⁺
• Genetic Background: CAnN.B6-Dis3^tm1.1Adki

cellular

chromosome breakage ( J:385017 )

• higher rate of oncogenic translocation in Igh locus in pristane-induced plasmacytomas

Genotype
MGI:8353848

ht3

• Allelic Composition: Dis3^tm1.1Adki/Dis3⁺
• Genetic Background: C57BL/6N-Dis3^tm1.1Adki

cellular

cellular phenotype ( J:385017 )

N • normal chromosome architecture in Igh locus

chromosome breakage ( J:385017 )

• higher rate of oncogenic translocation in Igh locus in pristane-induced plasmacytomas

growth/size/body

growth/size/body region phenotype ( J:385017 )

N • normal development

decreased body size ( J:385017 )

hematopoietic system

hematopoietic system phenotype ( J:385017 )

N • normal hematological development

N • normal class switch recombination (CSR) and somatic hypermutation (SHM)

homeostasis/metabolism

ascites ( J:385017 )

• increased fluid accumulation following intraperitoneal pristane injection

neoplasm

increased plasmacytoma incidence ( J:385017 )

• more frequent and more rapid following intraperitoneal pristane injection