Plekhf1 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Plekhf1
pleckstrin homology domain containing, family F (with FYVE domain) member 1
MGI:1919537

9 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Plekhf1^{em1(IMPC)Wtsi}/Plekhf1^{em1(IMPC)Wtsi} C57BL/6N-Plekhf1^{em1(IMPC)Wtsi}/Wtsi	preweaning lethality, complete penetrance	J:211773
Plekhf1^tm1.1Caox/Plekhf1^tm1.1Caox Lyz2^tm1(cre)Ifo/Lyz2⁺ B6.Cg-Plekhf1^tm1.1Caox Lyz2^tm1(cre)Ifo	abnormal cytokine secretion	J:277440
	abnormal endocytosis	J:277440
	abnormal macrophage physiology	J:277440
	decreased circulating interferon-beta level	J:277440
	decreased circulating interleukin-6 level	J:277440
	decreased circulating tumor necrosis factor level	J:277440
	increased susceptibility to bacterial infection	J:277440
	increased susceptibility to bacterial infection induced morbidity/mortality	J:277440

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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