Med27 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Med27
mediator complex subunit 27
MGI:1916225

22 phenotypes from 2 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Med27^em1(IMPC)Bay/Med27⁺ C57BL/6N-Med27^em1(IMPC)Bay/Bay	abnormal retina blood vessel morphology	J:211773
Med27^em1(IMPC)Bay/Med27^em1(IMPC)Bay C57BL/6N-Med27^em1(IMPC)Bay/Bay	preweaning lethality, complete penetrance	J:211773
Med27^tm1.1Xfa/Med27^tm1.1Xfa involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	no abnormal phenotype detected	J:379748
Med27^tm1.1Xfa/Med27^tm1.1Xfa A1cf^{Tg(Myh6-cre/Esr1)1Jmk}/A1cf⁺ involves: 129S1/Sv 129X1/SvJ * C57BL/6 * FVB/N * SJL	cardiac fibrosis	J:379748
	congestive heart failure	J:379748
	decreased heart left ventricle muscle contractility	J:379748
	decreased protein level	J:379748
	dilated cardiomyopathy	J:379748
	dilated heart left ventricle	J:379748
	dilated heart ventricle	J:379748
	increased myocardial fiber apoptosis	J:379748
	premature death	J:379748
Med27^tm1.1Xfa/Med27^tm1.1Xfa Tg(Tnnt2-cre)5Blh/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 * SJL	abnormal cardiovascular development	J:379748
	abnormal heart development	J:379748
	decreased fetal cardiomyocyte proliferation	J:379748
	decreased protein level	J:379748
	embryonic lethality during organogenesis, complete penetrance	J:379748
	internal hemorrhage	J:379748
	pericardial edema	J:379748
	thin left ventricle myocardium compact layer	J:379748
	thin right ventricle myocardium compact layer	J:379748
	thin ventricle myocardium compact layer	J:379748
	thin ventricular wall	J:379748

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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