Med27^tm1.1Xfa
Targeted Allele Detail

Summary

• Symbol: Med27^tm1.1Xfa
• Name: mediator complex subunit 27; targeted mutation 1.1, Xi Fang
• MGI ID: MGI:8291593
• Synonyms: Med27^flox
• Gene: Med27 Location: Chr2:29236831-29414805 bp, + strand Genetic Position: Chr2, 19.84 cM, cytoband A3
• Alliance: Med27^tm1.1Xfa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:379748
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector floxed exon 3. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. (J:379748)

Expression

In Mice Carrying this Mutation:	64 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Med27 Mutation: 28 strains or lines available

References

• Original: J:379748 Zhu S, et al., The essential role of MED27 in stabilizing the mediator complex for cardiac development and function. Life Sci. 2024 Nov 1;356:123020
• All: 1 reference(s)