Chd8 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Chd8
chromodomain helicase DNA binding protein 8
MGI:1915022

32 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Chd8^em1(IMPC)Mbp/Chd8⁺ C57BL/6N-Chd8^em1(IMPC)Mbp/MbpMmucd	decreased locomotor activity	J:211773
Chd8^em1(IMPC)Mbp/Chd8^em1(IMPC)Mbp C57BL/6N-Chd8^em1(IMPC)Mbp/MbpMmucd	embryonic lethality prior to organogenesis	J:211773
	preweaning lethality, complete penetrance	J:211773
Chd8^tm1.1Csbd/Chd8⁺ involves: C57BL/6J	abnormal brain morphology	J:267025
	abnormal miniature inhibitory postsynaptic currents	J:267025
	abnormal nervous system electrophysiology	J:267025
	abnormal neuron physiology	J:267025
	abnormal social/conspecific interaction behavior	J:267025
	decreased locomotor activity	J:267025
	decreased miniature inhibitory postsynaptic current amplitude	J:267025
	decreased miniature inhibitory postsynaptic current frequency	J:267025
	excessive vocalization	J:267025
	increased grooming behavior	J:267025
	increased miniature inhibitory postsynaptic current frequency	J:267025
	increased thigmotaxis	J:267025
Chd8^tm1Kei/Chd8⁺ involves: 129P2/OlaHsd * C57BL/6J	abnormal intestinal transit time	J:235128
	abnormal social investigation	J:235128
	decreased intestine length	J:235128
	decreased startle reflex	J:235128
	increased anxiety-related response	J:235128
	increased brain weight	J:235128
	increased prepulse inhibition	J:235128
	megacephaly	J:235128
Chd8^tm1Kei/Chd8^tm1Kei involves: C57BL/6	abnormal inner cell mass morphology	J:92968
	absent mesoderm	J:92968
	embryonic growth arrest	J:92968
	embryonic lethality, complete penetrance	J:92968
	failure of primitive streak formation	J:92968
	increased ectoderm apoptosis	J:92968
	inner cell mass degeneration	J:92968
Chd8^tm2.1Kei/Chd8⁺ B6J.129P2-Chd8^tm2.1Kei	abnormal intestinal transit time	J:235128
	abnormal nervous system development	J:235128
	abnormal social investigation	J:235128
	decreased intestine length	J:235128
	decreased startle reflex	J:235128
	impaired learning	J:235128
	increased anxiety-related response	J:235128
	increased brain weight	J:235128
	increased prepulse inhibition	J:235128
	megacephaly	J:235128
Chd8^tm2.1Kei/Chd8^tm2.1Kei involves: 129P2/OlaHsd * C57BL/6J	embryonic lethality during organogenesis, complete penetrance	J:235128

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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