Sbds Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sbds
SBDS ribosome maturation factor
MGI:1913961

34 phenotypes from 7 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sbds^{em1(SBDS)Dbau}/Sbds^{em1(SBDS)Dbau} C57BL/6J-Sbds^{em1(SBDS*)Dbau}/Dbau	abnormal ribosome biogenesis	J:335832
	lethality throughout fetal growth and development, complete penetrance	J:335832
Sbds^tm1.1Aljw/Sbds^tm1.1Aljw involves: BALB/cJ	embryonic lethality, complete penetrance	J:171416
Sbds^tm1Aljw/Sbds^tm1.1Aljw Tg(Mx1-cre)1Cgn/0 involves: BALB/cJ * C57BL/6 * DBA	abnormal hepatocyte physiology	J:171416
	abnormal liver morphology	J:171416
	hepatic necrosis	J:171416
Sbds^tm1Dats/Sbds^tm1Dats Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 involves: C57BL/6 * CD-1	abnormal bone marrow morphology	J:158901
	abnormal bone structure	J:158901
	abnormal cardiovascular system morphology	J:158901
	abnormal megakaryocyte morphology	J:158901
	abnormal myeloid leukocyte morphology	J:158901
	abnormal neutrophil morphology	J:158901
	decreased B cell number	J:158901
	decreased leukocyte cell number	J:158901
	decreased lymphocyte cell number	J:158901
	impaired hematopoiesis	J:158901
Sbds^tm1Jrom/Sbds⁺ involves: 129S6/SvEvTac * C57BL/6J	no abnormal phenotype detected	J:112167
Sbds^tm1Jrom/Sbds^tm1Jrom involves: 129S6/SvEvTac * C57BL/6J	abnormal embryonic tissue morphology	J:112167
	absent inner cell mass proliferation	J:112167
	absent proamniotic cavity	J:112167
	decreased embryo size	J:112167
	embryonic growth arrest	J:112167
	embryonic lethality between implantation and somite formation, complete penetrance	J:112167
	failure to gastrulate	J:112167
Sbds^tm1Jrom/Sbds^tm3.1Jrom Ptf1a^tm1(cre)Cvw/Ptf1a⁺ involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ	abnormal pancreatic islet size	J:189357
	decreased body length	J:189357
	decreased circulating amylase level	J:189357
	impaired glucose tolerance	J:189357
	pancreas hypoplasia	J:189357
	postnatal growth retardation	J:189357
	small pancreas	J:189357
Sbds^tm2.1Jrom/Sbds^tm2.1Jrom Not Specified	normal embryo phenotype	J:189357
Sbds^tm2.1Jrom/Sbds^tm3.1Jrom Ptf1a^tm1(cre)Cvw/Ptf1a⁺ involves: 129S1/Sv * 129X1/SvJ	abnormal pancreatic islet size	J:189357
	decreased body length	J:189357
	decreased circulating amylase level	J:189357
	normal embryo phenotype	J:189357
	pancreas lipomatosis	J:189357
	pancreatic acinar hypoplasia	J:189357
	postnatal growth retardation	J:189357
	small pancreas	J:189357

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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