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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Dkc1
dyskeratosis congenita 1, dyskerin
MGI:1861727
70 phenotypes from 6 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Dkc1tm1.1Pjma/Y
B6.129X1(FVB)-Dkc1tm1.1Pjma
abnormal cell physiology J:217050
decreased B cell number J:217050
decreased body weight J:217050
decreased fibroblast proliferation J:217050
decreased hematopoietic stem cell proliferation J:217050
decreased T cell number J:217050
oxidative stress J:217050
Dkc1tm1.1Pjma/Y
involves: 129X1/SvJ * C57BL/6 * FVB/N
abnormal DNA repair J:138335
normal hematopoietic system phenotype J:138335
normal integument phenotype J:138335
Dkc1tm1.1Pjma/Dkc1+
involves: 129X1/SvJ * C57BL/6 * FVB/N
abnormal hematopoietic system morphology/development J:138335
Dkc1tm1Bsl/Y
involves: 129/Sv * C57BL/6
no abnormal phenotype detected J:80494
Dkc1tm1Bsl/Dkc1+
Tg(Gata1-cre)1Sho/0
involves: 129/Sv * C57BL/6 * CD-1
abnormal embryo development J:80494
decreased embryo size J:80494
embryonic growth arrest J:80494
embryonic lethality during organogenesis, complete penetrance J:80494
failure of initiation of embryo turning J:80494
increased trophectoderm apoptosis J:80494
transmission ratio distortion J:80494
trophectoderm cell degeneration J:80494
Dkc1tm1Bsl/Dkc1tm1Bsl
involves: 129/Sv * C57BL/6
no abnormal phenotype detected J:80494
Dkc1tm1Bsl/Y
Tg(Gata1-cre)1Sho/0
involves: 129/Sv * C57BL/6 * CD-1
embryonic lethality between implantation and somite formation, complete penetrance J:80494
Dkc1tm1Ppp/Dkc1+
involves: 129S1/Sv
abnormal bone marrow cell morphology/development J:81054
abnormal cell morphology J:81054
abnormal cell physiology J:81054
abnormal definitive hematopoiesis J:81054
abnormal erythrocyte morphology J:81054
abnormal hematopoietic system physiology J:81054
abnormal immune system cell morphology J:81054
abnormal immune system organ morphology J:81054
abnormal kidney morphology J:81054
abnormal lung morphology J:81054
abnormal skin morphology J:81054
increased tumor incidence J:81054
Dkc1tm1Ppp/Y
involves: 129S1/Sv
abnormal bone marrow cell physiology J:81054
abnormal cell physiology J:81054
abnormal definitive hematopoiesis J:81054
abnormal epidermis stratum granulosum morphology J:81054
abnormal epidermis stratum spinosum morphology J:81054
abnormal proximal convoluted tubule morphology J:81054
abnormal pulmonary alveolar parenchyma morphology J:81054
abnormal pulmonary alveolus morphology J:81054
abnormal pulmonary alveolus wall morphology J:81054
abnormal spleen morphology J:81054
anemia J:81054
decreased B cell number J:81054
decreased bone marrow cell number J:81054
decreased common myeloid progenitor cell number J:81054
decreased erythroid progenitor cell number J:81054
decreased hemoglobin content J:81054
decreased leukocyte cell number J:81054
decreased lymphocyte cell number J:81054
decreased pre-B cell number J:81054
decreased spleen red pulp amount J:81054
decreased spleen white pulp amount J:81054
decreased telomere length J:81054
dyskeratosis J:81054
enlarged spleen J:81054
epidermal hyperplasia J:81054
extramedullary hematopoiesis J:81054
glomerulosclerosis J:81054
increased B cell derived lymphoma incidence J:81054
increased fibroblast apoptosis J:81054
increased fibrosarcoma incidence J:81054
increased lung carcinoma incidence J:81054
increased malignant tumor incidence J:81054
increased mammary adenocarcinoma incidence J:81054
increased pheochromocytoma incidence J:81054
increased renal carcinoma incidence J:81054
increased total body fat amount J:81054
lung inflammation J:81054
pulmonary interstitial fibrosis J:81054
renal tubule atrophy J:81054
thrombocytopenia J:81054
Dkc1tm2Bsl/Y
involves: 129/Sv * C57BL/6
no abnormal phenotype detected J:80494
Dkc1tm2Bsl/Dkc1+
Tg(Gata1-cre)1Sho/0
involves: 129/Sv * C57BL/6 * CD-1
abnormal embryo development J:80494
decreased embryo size J:80494
embryonic growth arrest J:80494
embryonic lethality during organogenesis, complete penetrance J:80494
failure of initiation of embryo turning J:80494
increased trophectoderm apoptosis J:80494
transmission ratio distortion J:80494
trophectoderm cell degeneration J:80494
Dkc1tm2Bsl/Dkc1tm2Bsl
involves: 129/Sv * C57BL/6
no abnormal phenotype detected J:80494
Dkc1tm2Bsl/Y
Tg(Gata1-cre)1Sho/0
involves: 129/Sv * C57BL/6 * CD-1
embryonic lethality between implantation and somite formation, complete penetrance J:80494
Dkc1tm2Pjma/Y
chimera involves: 129X1/SvJ * C57BL/6J
abnormal cell physiology J:149894
abnormal fertility/fecundity J:149894
Dkc1tm3Pjma/Y
involves: 129X1/SvJ * C57BL/6J
no abnormal phenotype detected J:149894
Dkc1tm3Pjma/Dkc1tm3Pjma
involves: 129X1/SvJ * C57BL/6J
no abnormal phenotype detected J:149894

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory