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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Sphk2
sphingosine kinase 2
MGI:1861380
35 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background
Annotated Term Reference
Lyve1tm1.1(EGFP/cre)Cys/Lyve1+
Sphk1tm2Cgh/Sphk1tm2Cgh
Sphk2tm1.1Cgh/Sphk2tm1.1Cgh
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
abnormal leukocyte migration J:156826
abnormal lymph node morphology J:156826
abnormal lymphatic vessel morphology J:156826
abnormal lymphocyte cell number J:156826
abnormal Peyer's patch T cell area morphology J:156826
decreased B cell number J:156826
decreased splenocyte number J:156826
decreased T cell number J:156826
normal immune system phenotype J:156826
Sphk1tm1.1Cgh/Sphk1tm2Cgh
Sphk2tm1.1Cgh/Sphk2tm1.1Cgh
Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJae * C57BL/6 * CBA
abnormal immune serum protein physiology J:120783
abnormal NK cell differentiation J:154069
abnormal T cell differentiation J:120783
abnormal thymus cell ratio J:120783
decreased B cell number J:120783
decreased bone marrow cell number J:120783
decreased NK cell number J:154069
decreased T cell number J:120783
hemorrhage J:205423
increased NK cell number J:154069
increased vascular permeability J:205423
Sphk1tm1Rlp/Sphk1tm1Rlp
Sphk2tm1Rlp/Sphk2tm1Rlp
involves: 129S6/SvEvTac * C57BL/6
abnormal blood vessel morphology J:103755
abnormal dorsal aorta morphology J:103755
abnormal embryonic neuroepithelium morphology J:103755
abnormal vascular endothelial cell morphology J:103755
abnormal vascular smooth muscle morphology J:103755
decreased embryonic neuroepithelium thickness J:103755
dilated brain ventricle J:103755
embryonic lethality during organogenesis, complete penetrance J:103755
exencephaly J:103755
hemopericardium J:103755
hemorrhage J:103755
incomplete rostral neuropore closure J:103755
increased embryonic neuroepithelium apoptosis J:103755
increased hindbrain apoptosis J:103755
increased midbrain apoptosis J:103755
intracranial hemorrhage J:103755
intraventricular hemorrhage J:103755
spinal hemorrhage J:103755

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory