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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Tcirg1
T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3
MGI:1350931
65 phenotypes from 6 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Tcirg1M1Jeau/Tcirg1+
either: (involves: C3H/HeJ * C57BL/6) or (involves: C3H/HeJ * C57BL/6 * FVB/N)
abnormal osteoclast morphology J:196503
abnormal osteoclast physiology J:196503
abnormal trabecular bone morphology J:196503
increased bone mineral content J:196503
increased bone mineral density J:196503
increased osteoclast cell number J:196503
increased trabecular bone mass J:196503
normal skeleton phenotype J:196503
Tcirg1oc/Tcirg1oc
B6C3Fe a/a-Tcirg1oc/J
abnormal incisor morphology J:7870
abnormal long bone hypertrophic chondrocyte zone J:7766
abnormal long bone metaphysis morphology J:7766, J:7870
abnormal osteoclast morphology J:7870
abnormal predentin morphology J:7870
abnormal thyroid gland morphology J:7870
circling J:7870, J:61295
decreased body size J:7870, J:61295
decreased body weight J:7870
decreased circulating insulin level J:116082
decreased insulin secretion J:116082
delayed tooth eruption J:7870, J:61295
extramedullary hematopoiesis J:7870
failure of bone resorption J:7766
increased long bone epiphyseal plate size J:7766, J:7870
increased megakaryocyte cell number J:7870
increased width of hypertrophic chondrocyte zone J:7766
osteopetrosis J:7870
postnatal lethality, complete penetrance J:7870
weight loss J:7870
Tcirg1oc/Tcirg1oc
C57BL/6J-Vps33abf
abnormal bone ossification J:28464
absent teeth J:28464
circling J:28464
clubfoot J:28464
failure of bone resorption J:28464
premature death J:28464
Tcirg1tm1.1Ywd/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
normal cellular phenotype J:150327
Tcirg1tm1.1Ywd/Tcirg1tm1.1Ywd
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
no abnormal phenotype detected J:150327
Tcirg1tm1.2Ywd/Tcirg1tm1.2Ywd
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL
abnormal macrophage physiology J:150327
absent teeth J:150327
decreased body size J:150327
premature death J:150327
Tcirg1tm1Utku/Tcirg1tm1Utku
involves: 129X1/SvJ * C57BL/6
abnormal immune serum protein physiology J:92730
abnormal immune system physiology J:92730
abnormal mesenteric lymph node morphology J:92730
abnormal peripheral lymph node morphology J:92730
abnormal Peyer's patch morphology J:92730
abnormal spleen B cell corona morphology J:92730
abnormal spleen morphology J:92730
abnormal spleen periarteriolar lymphoid sheath morphology J:92730
abnormal spleen red pulp morphology J:92730
abnormal spleen white pulp morphology J:92730
decreased B cell number J:92730
decreased body weight J:92730
decreased lymphocyte cell number J:92730
decreased spleen B cell follicle size J:92730
decreased T cell number J:92730
increased granulocyte number J:92730
increased IgG1 level J:92730
increased IgG2a level J:92730
increased IgM level J:92730
increased immunoglobulin level J:92730
increased spleen germinal center number J:92730
postnatal growth retardation J:92730
thymus atrophy J:92730
Tcirg1tm1Ypl/Tcirg1tm1Ypl
involves: 129S4/SvJae * C57BL/6J
abnormal bone marrow cavity morphology J:58795
abnormal bone mineralization J:224711
abnormal long bone hypertrophic chondrocyte zone J:58795
abnormal long bone metaphysis morphology J:224711
abnormal osteoclast physiology J:58795
absent compact bone J:224711
absent teeth J:58795
decreased body weight J:58795
decreased circulating calcium level J:224711
decreased compact bone thickness J:58795
decreased vitamin D level J:224711
failure of tooth eruption J:58795
increased bone mineral density J:58795
osteopetrosis J:58795, J:224711
premature death J:58795
rickets J:224711
short limbs J:58795

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory